Musharaf I, Nashwan AJ. Metabolic dynamics in chronic gastritis: Examining urinary profiles post Helicobacter pylori eradication. World J Clin Cases 2024; 12(16): 2698-2700 [PMID: 38899295 DOI: 10.12998/wjcc.v12.i16.2698]
Corresponding Author of This Article
Abdulqadir J Nashwan, MSc, Research Scientist, Department of Nursing, Hamad Medical Corporation, Rayyan Road, Doha 3050, Qatar. anashwan@hamad.qa
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Editorial
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Jun 6, 2024; 12(16): 2698-2700 Published online Jun 6, 2024. doi: 10.12998/wjcc.v12.i16.2698
Metabolic dynamics in chronic gastritis: Examining urinary profiles post Helicobacter pylori eradication
Imshaal Musharaf, Abdulqadir J Nashwan
Imshaal Musharaf, Department of Medicine, Jinnah Sindh Medical University, Karachi 0000, Pakistan
Abdulqadir J Nashwan, Department of Nursing, Hamad Medical Corporation, Doha 3050, Qatar
Author contributions: Musharaf I and Nashwan AJ wrote the draft and critically reviewed the literature.
Conflict-of-interest statement: All the authors declare that they have no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Abdulqadir J Nashwan, MSc, Research Scientist, Department of Nursing, Hamad Medical Corporation, Rayyan Road, Doha 3050, Qatar. anashwan@hamad.qa
Received: February 4, 2024 Revised: March 3, 2024 Accepted: April 1, 2024 Published online: June 6, 2024 Processing time: 114 Days and 20.2 Hours
Abstract
Chronic gastritis is the persistent and insidious inflammation of the gastric lining. Helicobacter pylori (H. pylori) has been identified as the most common cause of chronic gastritis and consequently elimination of H. pylori can lead to its cure. This editorial explores the use of urinary metabolic profiles before and after eradication to identify biomarkers that can aid in prognosis and treatment. Despite providing promising insights, there are limitations such as a small sample size (17 patients), a narrow treatment period of 2 wk, and treatment heterogeneity, which raise concerns. Nevertheless, these findings have opened a gateway to enhancing the treatment and prognosis of chronic gastritis through urinary metabolomics.
Core Tip: The study explores the metabolic changes associated with the eradication of Helicobacter pylori (H. pylori) in H. pylori-positive chronic gastritis and accentuates the potential use of urinary metabolites as biomarkers for early prognosis and effective treatment. However, certain limitations such as a restricted sample size, short treatment duration, and treatment homogeneity reduced the potency of the study. A more extensive and standardized investigation is required.
