Xu P, Ling SS, Hu E, Yi BX. Pleomorphic rhabdomyosarcoma of the vagina: A case report. World J Clin Cases 2024; 12(14): 2396-2403 [PMID: 38765737 DOI: 10.12998/wjcc.v12.i14.2396]
Corresponding Author of This Article
Pan Xu, MD, Director, Department of Gynecology, The Affiliated Jinhua Hospital of Wenzhou Medical University, No. 267 Danxi East Street, Jinhua 321000, Zhejiang Province, China. xupan033@163.com
Research Domain of This Article
Obstetrics & Gynecology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. May 16, 2024; 12(14): 2396-2403 Published online May 16, 2024. doi: 10.12998/wjcc.v12.i14.2396
Pleomorphic rhabdomyosarcoma of the vagina: A case report
Pan Xu, Shan-Shan Ling, E Hu, Bi-Xia Yi
Pan Xu, Shan-Shan Ling, E Hu, Bi-Xia Yi, Department of Gynecology, The Affiliated Jinhua Hospital of Wenzhou Medical University, Jinhua 321000, Zhejiang Province, China
Pan Xu, Zhejiang University School of Medicine, Hangzhou 310006, Zhejiang Province, China
Co-first authors: Pan Xu and Shan-Shan Ling.
Author contributions: Xu P and Ling SS contributed equally to this work and wrote the main manuscript; Hu E prepared the figures; Xu P and Yi BX revised the final manuscript; all authors read and approved the final manuscript.
Supported byThe Science and Technology Bureau Foundation of Jinhua, No. 2021-4-300 and No. 2020-3-062.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest in relation to this case report.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Pan Xu, MD, Director, Department of Gynecology, The Affiliated Jinhua Hospital of Wenzhou Medical University, No. 267 Danxi East Street, Jinhua 321000, Zhejiang Province, China. xupan033@163.com
Received: January 23, 2024 Revised: February 15, 2024 Accepted: April 3, 2024 Published online: May 16, 2024
Abstract
BACKGROUND
Rhabdomyosarcoma (RMS) of the vagina in postmenopausal women is an extremely rare malignant tumor that was originally described as a unique group of soft tissue sarcomas originating from primitive mesenchymal cells. It was first reported in postmenopausal women in 1970, and fewer than 50 postmenopausal patients have been reported to date.
CASE SUMMARY
A 68-year-old multiparous female was admitted to the hospital on October 11, 2023, with the chief complaint of a mass causing vaginal prolapse with incomplete urination that had persisted for 4 months. The vaginal mass was approximately the size of a pigeon egg; after lying down, the vaginal mass retracted. Complete resection was performed, and vaginal pleomorphic RMS was diagnosed based on pathology and immunohistochemical staining features. The patient is currently undergoing chemotherapy. The present study also reviewed the clinical, histological, and immunohistochemical features and latest treatment recommendations for vaginal RMS. Any abnormal vaginal mass should be promptly investigated through pelvic examination and appropriate imaging. The current initial treatment for vaginal RMS is biopsy and primary chemotherapy.
CONCLUSION
When surgery is planned for vaginal RMS, an organ-preserving approach should be considered.
Core Tip: Rhabdomyosarcoma (RMS) of the vagina is an extremely rare malignant tumor in postmenopausal women. Here we describe a 68-year-old female admitted to hospital on October 11, 2023 with the chief complaint of a mass causing vaginal prolapse with incomplete urination that had persisted for 4 months. Complete resection was performed, and vaginal pleomorphic RMS was diagnosed based on pathology and immunohistochemical staining features. The patient is currently undergoing chemotherapy. This study also included review of the current literature to summarize clinical, histological, and immunohistochemical features of the postmenopausal vaginal RMS patients reported to date and latest treatment recommendations.
