Hu YA, Guo YX, Huang QF. Rim 18F-fluorodeoxyglucose uptake of hepatic cavernous hemangioma on positron emission tomography/computed tomography: A case report. World J Clin Cases 2024; 12(13): 2243-2247 [PMID: 38808338 DOI: 10.12998/wjcc.v12.i13.2243]
Corresponding Author of This Article
Qi-Feng Huang, MD, Doctor, Department of Nuclear Medicine, Jinhua Hospital of Zhejiang University, Jinhua Municipal Central Hospital, No. 365 Renmin East Road, Jinhua 321000, Zhejiang Province, China. 1156225010@qq.com
Research Domain of This Article
Nuclear Science & Technology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. May 6, 2024; 12(13): 2243-2247 Published online May 6, 2024. doi: 10.12998/wjcc.v12.i13.2243
Rim 18F-fluorodeoxyglucose uptake of hepatic cavernous hemangioma on positron emission tomography/computed tomography: A case report
Yong-An Hu, Ya-Xin Guo, Qi-Feng Huang
Yong-An Hu, Ya-Xin Guo, Qi-Feng Huang, Department of Nuclear Medicine, Jinhua Hospital of Zhejiang University, Jinhua Municipal Central Hospital, Jinhua 321000, Zhejiang Province, China
Author contributions: All authors were involved in the preparation of this manuscript. Hu YA participated in data collection and wrote the manuscript; Guo YX participated in literature search and wrote the manuscript; Huang QF wrote and revised the manuscript; all authors have read and agreed to the published version of the manuscript.
Supported byZhejiang Province Public Welfare Technology Application Research Project, No. LGF21H180007.
Informed consent statement: Written informed consent has been obtained from the patient to publish this paper.
Conflict-of-interest statement: All authors declare that they have no conflicts of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Qi-Feng Huang, MD, Doctor, Department of Nuclear Medicine, Jinhua Hospital of Zhejiang University, Jinhua Municipal Central Hospital, No. 365 Renmin East Road, Jinhua 321000, Zhejiang Province, China. 1156225010@qq.com
Received: November 28, 2023 Revised: February 21, 2024 Accepted: April 3, 2024 Published online: May 6, 2024 Processing time: 149 Days and 5.3 Hours
Abstract
BACKGROUND
Peripheral FDG accumulation in a hepatic hemangioma presenting in a patient with prolonged fever is rare. Therefore, clinicians should pay close attention to patients with hepatic mass.
CASE SUMMARY
A 54-year-old woman with a 4-wk history of daily fevers was admitted to our hospital. A whole body 18F-Fluordesoxyglucose (PET-FDG) positron emission tomography/computed tomography (PET/CT) was performed to elucidate the source of the fever. However, whole body 18F-FDG PET/CT raised the suspicion of a malignant lesion because of peripheral FDG accumulation (SUVmax 3.5 g/mL) higher than that of the normal liver parenchyma (SUVmax 1.6 g/mL) surrounding a hypoactive area, and no other abnormalities were showed. Subsequently, the patient underwent liver mass resection. Histopathology showed a hepatic cavernous hemangioma with fatty infiltration around the lesion. The fever disappeared four days after surgery and the patient did not present any complications during follow-up.
CONCLUSION
Fatty infiltration in the peripheral parts of hepatic cavernous hemangioma may lead to subacute inflammation which further activate the Kupffer cells. This may cause prolonged fever and peripheral rim FDG accumulation on PET/CT.
Core Tip: Most of the hepatic cavernous hemangiomas (HCHs) are small, asymptomatic, and detected incidentally. The typical characteristics of HCHs on computed tomography or magnetic resonance imaging make their diagnosis straightforward. It has been suggested that low uptake of fluorodeoxyglucose could be useful to distinguish between benign hemangioma and malignant liver lesions. However, in the case presented here, a pathologically confirmed hepatic cavernous hemangioma showed a SUVmax (maximum standardized uptake value) in the margin of the lesion which was higher than that of the normal liver parenchyma. Therefore, clinicians should pay close attention to patients with hepatic mass.
