Published online May 6, 2024. doi: 10.12998/wjcc.v12.i13.2173
Peer-review started: January 25, 2024
First decision: February 8, 2024
Revised: February 27, 2024
Accepted: March 25, 2024
Article in press: March 25, 2024
Published online: May 6, 2024
Multidrug-resistant Gram-negative bacteria, exacerbated by excessive use of anti
To study the clinical efficacy and safety of colistin sulfate in the treatment of car
This retrospective analysis involved 54 patients with Gram-negative bacilli pneumonia admitted to intensive care unit of The General Hospital of the Northern Theater Command of the People's Liberation Army of China from August 2020 to June 2022. After bacteriological culture, the patients' airway secretions were collected to confirm the presence of Gram-negative bacilli. The patients were divided into the experimental and control groups according to the medication used. The research group consisted of 28 patients who received polymyxin sulfate combined with other drugs through intravenous, nebulization, or intravenous combined with nebulization, with a daily dosage of 1.5–3.0 million units. The control group consisted of 26 patients who received standard dosages of other antibiotics (including sulbactam sodium for injection, cefoperazone sodium sulbactam for injection, tigecycline, meropenem, or vaborbactam).
Of the 28 patients included in the research group, 26 patients showed impro
Polymyxin sulfate has a significant effect on the treatment of patients with multiple drug-resistant Gram-negative bacilli pneumonia and other infections in the lungs and is safe and reliable. Moreover, the administration route of low-dose intravenous injection combined with nebulization shows better therapeutic effects and lower adverse reactions, providing new ideas for clinical administration.
Core Tip: Multidrug-resistant Gram-negative bacteria, exacerbated by excessive use of antimicrobials and immunosuppressants, are a major health threat. Colistin sulfate provides comprehensive, highly sensitive coverage against these bacteria. For pulmonary infections, its use via intravenous and nebulization methods improves cure rates and reduces adverse reactions, including renal and neurotoxicity. It also significantly ameliorates clinical symptoms in sepsis patients, proving to be safe and reliable.