Editorial
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Apr 26, 2024; 12(12): 2000-2003
Published online Apr 26, 2024. doi: 10.12998/wjcc.v12.i12.2000
Protein C deficiency with venous and arterial thromboembolic events
Nan Zhang, Dong-Kun Sun, Xu Tian, Xin-Yu Zheng, Tong Liu
Nan Zhang, Dong-Kun Sun, Xu Tian, Xin-Yu Zheng, Tong Liu, Department of Cardiology, Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Tianjin Institute of Cardiology, The Second Hospital of Tianjin Medical University, Tianjin 300211, China
Author contributions: Zhang N conceived the study and wrote the paper; Sun DK, Tian X, and Zheng XY reviewed the manuscript; Liu T edited and revised the manuscript; All authors have read and approved the final manuscript.
Conflict-of-interest statement: The authors declare that they have no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Tong Liu, PhD, Professor, Department of Cardiology, Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Tianjin Institute of Cardiology, The Second Hospital of Tianjin Medical University, No. 23 Pingjiang Road, Hexi District, Tianjin 300211, China. liutongdoc@126.com
Received: October 31, 2023
Peer-review started: October 31, 2023
First decision: January 17, 2024
Revised: January 28, 2024
Accepted: March 26, 2024
Article in press: March 26, 2024
Published online: April 26, 2024
Abstract

Protein C (PC) is a key component of the vitamin K-dependent coagulation pathway. It exerts anticoagulant effects by inactivating factors V and VIII. Acquired or inherited PC deficiency results in a prothrombotic state, with presentations varying from asymptomatic to venous thromboembolism. However, there has been an increasing number of reports linking PC deficiency to arterial thromboembolic events, such as myocardial infarction and ischemic stroke. This editorial focuses on the association between PC deficiency and thromboembolism, which may provide some insights for treatment strategy and scientific research.

Keywords: Protein C deficiency, Venous thromboembolism, Myocardial infarction, Editorial, Arterial thromboembolism

Core Tip: Protein C (PC) deficiency impairs the balance between the procoagulant and anticoagulant system, which results in venous thromboembolism. However, there has been an increasing number of reports linking the condition to arterial thromboembolic events. A thorough understanding of PC deficiency is essential for the development of new management strategies against PC deficiency-related thromboembolism events.