Ding JS, Zhang M, Zhou FF. Primary acinic cell carcinoma of the breast: A case report and review of literature. World J Clin Cases 2024; 12(1): 196-203 [PMID: 38292630 DOI: 10.12998/wjcc.v12.i1.196]
Corresponding Author of This Article
Fang-Fang Zhou, BSc, Doctor, Department of Ultrasound, Lishui Central Hospital, The Fifth Affiliated Hospital of Wenzhou Medical University, No. 289 Kuocang Road, Lishui 323000, Zhejiang Province, China. zf1006835371@163.com
Research Domain of This Article
Oncology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Jan 6, 2024; 12(1): 196-203 Published online Jan 6, 2024. doi: 10.12998/wjcc.v12.i1.196
Primary acinic cell carcinoma of the breast: A case report and review of literature
Jia-Sheng Ding, Min Zhang, Fang-Fang Zhou
Jia-Sheng Ding, Department of Intensive Care Unit, Lishui Central Hospital, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui 323000, Zhejiang Province, China
Min Zhang, Department of Pathology, Lishui Central Hospital, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui 323000, Zhejiang Province, China
Fang-Fang Zhou, Department of Ultrasound, Lishui Central Hospital, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui 323000, Zhejiang Province, China
Author contributions: Ding JS was responsible for collecting the medical history of the patient and drafting the paper; Zhang M is a pathologist who provided the pathological results; Zhou FF reviewed the literature and revised the manuscript; and all authors issued final approval for the version to be submitted.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Fang-Fang Zhou, BSc, Doctor, Department of Ultrasound, Lishui Central Hospital, The Fifth Affiliated Hospital of Wenzhou Medical University, No. 289 Kuocang Road, Lishui 323000, Zhejiang Province, China. zf1006835371@163.com
Received: October 12, 2023 Peer-review started: October 12, 2023 First decision: November 20, 2023 Revised: November 27, 2023 Accepted: December 20, 2023 Article in press: December 20, 2023 Published online: January 6, 2024 Processing time: 82 Days and 1.8 Hours
Abstract
BACKGROUND
In the current World Health Organization classification, acinic cell carcinoma (AcCC) of the breast is considered a rare histological subtype of triple-negative breast cancer. Because of the few reports in the literature, data concerning clinical outcomes are limited. Here, we report a case of AcCC of the breast in a 48-year-old woman.
CASE SUMMARY
A 48-year-old woman with a mass in her right breast came to our hospital for further diagnosis. Mammography and an ultrasound (US) scan showed a mass in the upper inner side of the right breast. She then underwent surgery to resect the mass in her right breast. Postoperative pathological examination revealed that the tumor had abundant acinar-like structures formed by tumor cells with prominent eosinophilic granules in the cytoplasm, consistent with acinar cell carcinoma. The results of immunohistochemical analysis supported the diagnosis of breast acinar cell carcinoma. Two months later, she underwent breast-conserving surgery and sentinel lymph node biopsy. The pTNM stage was T2N0M0. After surgery, the patient received 30 radiotherapy sessions. The patient was followed up for a period of one year, and no recurrence was found.
CONCLUSION
AcCC of the breast is a rare type of malignant tumor. Because it is usually asymptomatic and can be detected by imaging studies, routine breast US or mammograms are important. However, there are no characteristic diagnostic imaging findings or clinical manifestations, so immunohistochemical examination is critical for an accurate diagnosis of AcCC of the breast.
Core Tip: Acinic cell carcinoma (AcCC) of the breast is extremely rare. It is considered a clinically low-grade malignancy. Few cases of breast AcCC have been reported. AcCC of the breast is usually asymptomatic and can be detected by imaging studies. Routine breast ultrasound or mammograms are important. Herein, a 48-year-old woman with AcCC of the breast is reported.
