Case Report
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Mar 16, 2023; 11(8): 1808-1813
Published online Mar 16, 2023. doi: 10.12998/wjcc.v11.i8.1808
Giant juvenile fibroadenoma in a 14-year old Chinese female: A case report
Jing Wang, Dai-Di Zhang, Jia-Mao Cheng, Hai-Yan Chen, Rong-Jiao Yang
Jing Wang, Dai-Di Zhang, Hai-Yan Chen, Rong-Jiao Yang, Department of Ultrasound, First Affiliated Hospital of Dali University (The People’s Fourth Hospital of Yunnan Province), Dali 671000, Yunnan Province, China
Dai-Di Zhang, Hai-Yan Chen, Rong-Jiao Yang, Department of Ultrasound, School of Clinical Medicine, Dali University, Dali 671000, Yunnan Province, China
Jia-Mao Cheng, Department of Anatomy, College of Basic Medicine, Dali University, Dali 671000, Yunnan Province, China
Author contributions: Wang J performed the ultrasonic examination; Zhang DD contributed to the data curation and writing-original draft preparation; Cheng JM wrote the manuscript and reviewed and edited the manuscript; Chen HY involved in the visualization and validation; Yang RJ participated to the investigation of the manuscript.
Informed consent statement: Written informed consent was obtained from the patient for publication of this report and any accompanying images. We guarantee patient anonymity.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jia-Mao Cheng, MM, Assistant Professor, Department of Anatomy, College of Basic Medicine, Dali University, No. 2 Hongsheng Road, Dali 671000, Yunnan Province, China. chjmao@163.com
Received: November 18, 2022
Peer-review started: November 18, 2022
First decision: December 26, 2022
Revised: January 4, 2023
Accepted: February 16, 2023
Article in press: February 16, 2023
Published online: March 16, 2023
Processing time: 109 Days and 6.4 Hours
Abstract
BACKGROUND

A giant juvenile fibroadenoma (GJF) is a rare, benign breast tumor that affects females < 18 years of age. GJFs are generally suspected based on a palpable mass. GJFs influence breast shape and mammary gland development via the pressure effect from their enormous size.

CASE SUMMARY

Herein we report a case involving a 14-year-old Chinese female with a GJF in the left breast. GJF is a rare, benign breast tumor that usually occurs between 9 and 18 years of age and accounts for 0.5%-4.0% of all fibroadenomas. In severe cases, breast deformation may occur. This disease is rarely reported in Chinese people and has a high clinical misdiagnosis rate due to the absence of specific imaging features. On July 25, 2022, a patient with a GJF was admitted to the First Affiliated Hospital of Dali University. The preoperative clinical examination and conventional ultrasound diagnosis needed further clarification. The mass was shown to be an atypical lobulated mass during the operation and confirmed to be a GJF based on pathologic examination.

CONCLUSION

GJF is also a rare, benign breast tumor in Chinese women. Evaluation of such masses consists of a physical examination, radiography, ultrasonography, computer tomography, and magnetic resonance imaging. GJFs are confirmed by histopathologic examination. Mastectomy is not selected when the patient benefits from a complete resection of the mass with breast reconstruction and an uneventful recovery.

Keywords: Giant juvenile fibroadenoma; Fibroadenoma; Breast tumor; Ultrasonography; Case report

Core Tip: Giant juvenile fibroadenoma (GJF) is a rare benign breast tumor below 18 years of age and can be suspected mainly through palpable masses in clinical practice. Breast ultrasonography shows left masses > 5 cm with benign features (Breast Imaging Reporting and Data System score 3) through the preferred examination for breast imaging in this GJF case. The breast mass of GJF patients in this report showed a lobulated shape and many lobular ducts. Therefore, it is necessary to differentiate GJF from phosphotyrosine binding by histopathology. Clinicians should be aware of this diagnosis for a better approach and early conservative treatment instead of blindly performing mastectomy.