Feng JY, Jiang QP, He H. Endometriosis-associated endometrioid adenocarcinoma of the fallopian tube synchronized with endometrial adenocarcinoma: A case report. World J Clin Cases 2023; 11(6): 1365-1371 [PMID: 36926121 DOI: 10.12998/wjcc.v11.i6.1365]
Corresponding Author of This Article
Hong He, MD, PhD, Doctor, Professor, Department of Obstetrics and Gynecology, Guangdong Provincial Key Laboratory of Major Obstetric Disease, The Third Affiliated Hospital of Guangzhou Medical University, No. 63 Liwan District, Duobao Road, Guangzhou 510000, Guangdong Province, China. hehe200010@gzhmu.edu.cn
Research Domain of This Article
Obstetrics & Gynecology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Feb 26, 2023; 11(6): 1365-1371 Published online Feb 26, 2023. doi: 10.12998/wjcc.v11.i6.1365
Endometriosis-associated endometrioid adenocarcinoma of the fallopian tube synchronized with endometrial adenocarcinoma: A case report
Jian-Yang Feng, Qing-Ping Jiang, Hong He
Jian-Yang Feng, Hong He, Department of Obstetrics and Gynecology, Guangdong Provincial Key Laboratory of Major Obstetric Disease, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510000, Guangdong Province, China
Qing-Ping Jiang, Department of Pathology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510000, Guangdong Province, China
Author contributions: Feng JY contributed to primary manuscript writing, conceptualization, and data collection; Jiang QP contributed to pathologic review; He H contributed to manuscript editing, conceptualization, and supervision; all authors have read and approved the final manuscript.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors declare that they have no conflict of interest to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hong He, MD, PhD, Doctor, Professor, Department of Obstetrics and Gynecology, Guangdong Provincial Key Laboratory of Major Obstetric Disease, The Third Affiliated Hospital of Guangzhou Medical University, No. 63 Liwan District, Duobao Road, Guangzhou 510000, Guangdong Province, China. hehe200010@gzhmu.edu.cn
Received: October 14, 2022 Peer-review started: October 14, 2022 First decision: January 5, 2023 Revised: January 18, 2023 Accepted: February 7, 2023 Article in press: February 7, 2023 Published online: February 26, 2023 Processing time: 133 Days and 0.9 Hours
Abstract
BACKGROUND
Endometriosis is a common gynecological disorder that affects women of reproductive age. It is characterized by a cancer-like invasion of the extra-uterine endometrium and exhibits a strong association with ovarian clear cell cancer and endometrioid cancer. Endometriosis-associated fallopian tube endometrioid adenocarcinoma synchronized with endometrial adenocarcinoma was rarely reported.
CASE SUMMARY
A 49-year-old woman was referred to our hospital complaining about abnormal vaginal bleeding for three years following unsatisfactory medication. Intraoperative frozen sections unexpectedly unveiled an endometrioid cancer of the left fallopian tube with superficial invasion surrounded by diffuse endometriosis synchronized with endometrioid endometrial cancer.
CONCLUSION
It was difficult to make a differential diagnosis when confronted with incidental findings of fallopian tube cancer lesions synchronized with endometrial cancer. The key differential diagnosis of primary endometriosis-associated endometrioid adenocarcinoma of the fallopian tube from endometrial adenocarcinoma involvement relies on the pathological identification of malignant transformation in fallopian tube endometriosis disease.
Core Tip: The key to distinguishing primary endometriosis-associated fallopian tube cancer from fallopian tube involvement in endometrial cancer was the pathological identification of malignant transformation in endometriosis-associated fallopian tube tumors.
