Wang TT, Chen XY, Min QY, Han YZ, Zhao HF. Iris metastasis from clear cell renal cell carcinoma: A case report. World J Clin Cases 2023; 11(36): 8535-8541 [PMID: 38188215 DOI: 10.12998/wjcc.v11.i36.8535]
Corresponding Author of This Article
Huan-Fen Zhao, MM, Chief Physician, Professor, Department of Pathology, Hebei General Hospital, No. 348 Heping West Road, Shijiazhuang 050051, Hebei Province, China. hbghbinglike@126.com
Research Domain of This Article
Ophthalmology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Tong-Tong Wang, Yi-Ze Han, Department of Graduate School, Hebei Medical University, Shijiazhuang 050017, Hebei Province, China
Tong-Tong Wang, Xiao-Yue Chen, Qiao-Yun Min, Huan-Fen Zhao, Department of Pathology, Hebei General Hospital, Shijiazhuang 050051, Hebei Province, China
Qiao-Yun Min, School of Basic Medicine, Hebei North University, Zhangjiakou 075000, Hebei Province, China
Author contributions: Wang TT, Min QY, and Han YZ collected the clinical data and wrote the first draft; Chen XY and Zhao HF revised the draft; and all authors approved the final version, and agree to be accountable for the work and publish the final manuscript in this journal.
Informed consent statement: Written informed consent has been obtained from the patient for publication of this case report.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Huan-Fen Zhao, MM, Chief Physician, Professor, Department of Pathology, Hebei General Hospital, No. 348 Heping West Road, Shijiazhuang 050051, Hebei Province, China. hbghbinglike@126.com
Received: September 6, 2023 Peer-review started: September 6, 2023 First decision: November 1, 2023 Revised: November 14, 2023 Accepted: December 12, 2023 Article in press: December 12, 2023 Published online: December 26, 2023
Abstract
BACKGROUND
Clear cell renal cell carcinoma (ccRCC) is a common type of tumor that can metastasize to any organs and sites. However, it is extremely rare for ccRCC to metastasize to the iris. Here, we describe a rare case of iris metastasis from ccRCC with a history of left nephrectomy in 2010.
CASE SUMMARY
A 62-year-old male was admitted to the hospital due to blurred vision and red eyes, and a mass was found on the iris in the right eye. B-scan ultrasonography revealed a well-bounded high-density lesion at the corner of the anterior chamber at the 3-4 o’clock position. Phacoemulsification with simultaneous intraocular lens implantation and iridocyclectomy was performed in the right eye. The lesion was confirmed to be metastatic ccRCC by histological and immunohistochemical analyses. The patient was still alive at 9 mo after surgical treatment. Ocular metastasis can be an initial sign with a poor prognosis. Timely detection and treatment may improve survival. Clinicians should pay attention to similar metastatic diseases to prevent misdiagnosis leading to missed treatment opportunities.
CONCLUSION
This report of the characteristics and successful management of a rare case of iris metastasis from ccRCC highlights the importance of a comprehensive medical history, histopathology, immunohistochemistry, and clinical manifestation for successful disease diagnosis.
Core Tip: Here, we report a rare case of iris metastasis from clear cell renal cell carcinoma. We found that a complete medical history, histopathology, and immunohistochemistry combined with clinical manifestations are crucial for the successful diagnosis of this disease. In addition, a total of 11 cases of iris metastasis from renal tumors were identified in the literature and are reviewed in this report.
