Case Report
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Dec 6, 2023; 11(34): 8170-8175
Published online Dec 6, 2023. doi: 10.12998/wjcc.v11.i34.8170
Venous adventitial cystic disease is a very rare disease that can cause deep vein thrombosis: A case report
Miju Bae, Up Huh, Chung Won Lee, Jong Won Kim
Miju Bae, Up Huh, Chung Won Lee, Jong Won Kim, Department of Thoracic and Cardiovascular Surgery, Pusan National University School of Medicine, Busan 49241, South Korea
Miju Bae, Up Huh, Chung Won Lee, Jong Won Kim, Biomedical Research Institute, Pusan National University Hospital, Busan 49241, South Korea
Author contributions: Bae M, Huh U, and Lee CW contributed to subject assessment; Bae M, Huh U, Lee CW, and Kim JW contributed to drafting the manuscript and data interpretation; Bae M, Huh U, Lee CW, and Kim JW contributed to study conception, design, and supervision; All authors have read and approved the final manuscript.
Supported by the Bio&Medical Technology Development Program of the National Research Foundation (NRF) funded by the Korean government (MSIT), No. RS-2023-00223764.
Informed consent statement: Written informed consent was obtained from the patient for the publication of this study and any accompanying images. This study was approved by the Pusan National University Hospital Institutional Review Board.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Up Huh, MD, PhD, Assistant Professor, Surgeon, Department of Thoracic and Cardiovascular Surgery, Pusan National University School of Medicine, 179 Gudeok-Ro, Seo-Gu, Busan 49241, South Korea. tymfoo82@gmail.com
Received: August 28, 2023
Peer-review started: August 28, 2023
First decision: October 24, 2023
Revised: October 26, 2023
Accepted: November 28, 2023
Article in press: November 28, 2023
Published online: December 6, 2023
Processing time: 100 Days and 0 Hours
Abstract
BACKGROUND

Venous adventitial cystic disease (VACD) is a rare disease characterized by cysts, filled with a gelatinous mucous substance similar to joint fluid, in the adventitia of blood vessels adjacent to the joints. It is often misdiagnosed as deep vein thrombosis (DVT), femoral varices, venous tumors, or lymphadenopathy.

CASE SUMMARY

A 69-year-old woman visited our hospital with a complaint of swelling in the right lower extremity. The patient was diagnosed with DVT and prescribed apixaban at an outpatient clinic. After 3 wk, the patient was hospitalized again because of sudden swelling in the right lower extremity. We diagnosed VACD and performed surgery for cyst removal as well as patch angioplasty and thrombectomy of the right common femoral vein. The patient received anticoagulants for 6 mo and has been doing well without recurrence for 1 year postoperatively.

CONCLUSION

Recurrent VACD requires complete removal of the connections to the joint cavity to prevent recurrence.

Keywords: Adventitia; Cysts; Edema; Joints; Venous thrombosis; Case report

Core Tip: Venous adventitious cystic disease is a rare condition characterized by the occurrence of cysts filled with a gelatinous substance similar to synovial fluid in the outer layer of blood vessels adjacent to joints. It can be misdiagnosed as deep vein thrombosis, femoral varices, venous tumors, or lymphadenopathy. To prevent recurrence, it is important to completely remove the connections to the joint cavity.