Luo FR, Zhou Y, Wang Z, Liu QY. Cerebral proliferative angiopathy in pediatric age presenting as neurological disorders: A case report. World J Clin Cases 2023; 11(33): 8071-8077 [PMID: 38075565 DOI: 10.12998/wjcc.v11.i33.8071]
Corresponding Author of This Article
Qi-Yu Liu, MD, Chief Doctor, Professor, Department of Radiology, The Affiliated Hospital of Southwest Medical University, No. 25 Taiping Street, Luzhou 646000, Sichuan Province, China. lqy2225085@163.com
Research Domain of This Article
Neuroimaging
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Nov 26, 2023; 11(33): 8071-8077 Published online Nov 26, 2023. doi: 10.12998/wjcc.v11.i33.8071
Cerebral proliferative angiopathy in pediatric age presenting as neurological disorders: A case report
Fu-Ren Luo, Ying Zhou, Zhong Wang, Qi-Yu Liu
Fu-Ren Luo, Qi-Yu Liu, Department of Radiology, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, Sichuan Province, China
Ying Zhou, Zhong Wang, Department of Radiology, Mianyang Central Hospital, Mianyang 621000, Sichuan Province, China
Author contributions: Luo FR contributed to manuscript writing and editing and data collection; Wang Z contributed to data analysis; Zhou Y contributed to conceptualization and supervision; all authors have read and approved the final manuscript.
Informed consent statement: This report and the accompanying photographs have been published with a waiver of informed consent granted by the Ethical Review Board.
Conflict-of-interest statement: All the authors declare that they have no conflict of interest to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Qi-Yu Liu, MD, Chief Doctor, Professor, Department of Radiology, The Affiliated Hospital of Southwest Medical University, No. 25 Taiping Street, Luzhou 646000, Sichuan Province, China. lqy2225085@163.com
Received: September 9, 2023 Peer-review started: September 9, 2023 First decision: October 24, 2023 Revised: October 29, 2023 Accepted: November 14, 2023 Article in press: November 14, 2023 Published online: November 26, 2023
Abstract
BACKGROUND
Cerebral proliferative angiopathy (CPA) is a rare subtype of arteriovenous malformation. It is extremely rare in pediatric patients and has serious implications for developing children. However, reports of these disorders worldwide are limited, and no uniform reference for diagnosis and treatment options exists. We report the case of a 6-year-old with CPA having predominantly neurological dysfunction and review the literature on pediatric CPA.
CASE SUMMARY
We report the case of a pediatric patient with CPA analyzed using digital subtraction angiography (DSA) who presented initially with a neurological disorder as the main manifestation. This case is the basis for further discussion of the clinical presentation, pathogenesis, diagnosis, and treatment of CPA in children. After the cerebral DSA, the patient was treated conservatively with sedation, fluid replacement, and blood anticoagulation. She could not cooperate with the follow-up magnetic resonance imaging examination because of her young age, and her family declined further treatment because of the surgery’s high risk. She was followed up for 3 months; her symptoms did not worsen.
CONCLUSION
This report of rare pediatric CPA can inform and advance clinical research on congenital cerebrovascular diseases.
Core Tip: Cerebral proliferative angiopathy (CPA) is a type of ischemic cerebrovascular disease that is extremely rare in pediatric patients and has serious implications for developing children. However, reports of these disorders are limited, and no uniform reference for diagnosis and treatment options exists. This article reviews the literature on pediatric CPA from a case of CPA in a child with predominantly neurological dysfunction. We summarize the relevant clinical, diagnostic, therapeutic, and pathogenic explorations and provide suggestions for subsequent research on this disorder.
