Published online Nov 26, 2023. doi: 10.12998/wjcc.v11.i33.7972
Peer-review started: September 13, 2023
First decision: September 28, 2023
Revised: October 11, 2023
Accepted: October 30, 2023
Article in press: October 30, 2023
Published online: November 26, 2023
Processing time: 72 Days and 0.8 Hours
Acute myelitis (AM) can lead to sudden sensory, motor and autonomic nervous dysfunction, which negatively affects their daily activities and quality of life, so it is necessary to explore optimization from a therapeutic perspective to curb the progression of the disease.
To investigate the effect of ganglioside (GM) combined with methylprednisolone sodium succinate (MPSS) on the curative effect and neurological function of patients with AM.
First, we selected 108 AM patients visited between September 2019 and September 2022 and grouped them based on treatment modality, with 52 patients receiving gamma globulin (GG) + MPSS and 56 patients receiving GM + MPSS, assigned to the control group (Con) and observation group (Obs), respectively. The thera
The Obs had: (1) A significantly higher response rate of treatment than the Con; (2) Higher scores of sensory and motor functions after treatment that were higher than the baseline (before treatment) and higher than the Con levels; (3) Lower incidence rates of skin rash, gastrointestinal discomfort, dyslipidemia, osteoporosis and other AEs; (4) Faster posttreatment recovery of sphincter function, limb muscle strength and ambulation; and (5) Markedly lower posttreatment IL-6, CRP and TNF-α levels than the baseline and the Con levels.
From the above, it can be seen that GM + MPSS is highly effective in treating AM, with a favorable safety profile comparable to that of GG + MPSS. It can significantly improve patients’ neurological function, speed up their recovery and inhibit serum IFs.
Core Tip: Acute myelitis (AM) is an autoimmune demyelinating disease in which patients may experience clinical symptoms such as difficult defecation, nerve root pain, lower limb paralysis, low-grade fever, and other symptoms that lead to limitations in daily life. This study mainly verified the clinical advantages of ganglioside + methylprednisolone sodium succinate in the treatment of AM, so as to provide timely and effective treatment for patients with AM and improve the condition and prognosis of patients.