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©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
Malignant peripheral nerve sheath tumor with hemophilic syndrome and bone marrow fibrosis: A rare case report
Hui Li, Li Wang, Ying-Hong Wu, Gang Chen, Hong-Xia Li, Li-Fen Fan, Min Gu, Cai-Hong Jiang
Hui Li, Hong-Xia Li, Min Gu, Cai-Hong Jiang, Department of Medical Oncology, Ordos Central Hospital, Ordos 017000, Inner Mongolia Autonomous Region, China
Li Wang, Department of Pathology, Ordos Central Hospital, Ordos 017000, Inner Mongolia Autonomous Region, China
Ying-Hong Wu, Department of Neurology, Baogang Hospital, Baotou 014010, Inner Mongolia Autonomous Region 014010, China
Gang Chen, Department of Pharmacy, Ordos Central Hospital, Ordos 017000, Inner Mongolia Autonomous Region, China
Li-Fen Fan, Department of Orthopedics, Ordos Central Hospital, Ordos 017000, Inner Mongolia Autonomous Region, China
Co-first authors: Hui Li and Li Wang.
Author contributions: Jiang CH made substantial contributions to conception and design. Li H, Wang L, Wu YH and Chen G took part in drafting the article or revising it critically for important intellectual content; Li HX, Fan LF, and Gu M were responsible for organizing, collecting, and verifying clinical case data for this article; All authors agreed to submit to the current journal; gave final approval of the version to be published; and agree to be accountable for all aspects of the work; Li H is the supervising physician of the patient in this article, and Wang L is the pathological diagnostic physician of the patient; during the hospitalization and follow-up period of the patient, the two of them jointly traced the changes in the patient's condition and diagnosis and treatment; They jointly collected, organized, and wrote the preliminary data of the case report, so they are considered as the co-first authors.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All the author declares that they have no competing interests in this study.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
https://creativecommons.org/Licenses/by-nc/4.0/ Corresponding author: Cai-Hong Jiang, MD, Doctor, Department of Medical Oncology, Ordos Central Hospital, No. 23 Ejin Horo West Street, Dongsheng District, Ordos 017000, Inner Mongolia Autonomous Region, China. zxlihui2003@163.com
Received: August 22, 2023
Peer-review started: August 22, 2023
First decision: September 26, 2023
Revised: September 29, 2023
Accepted: October 16, 2023
Article in press: October 16, 2023
Published online: November 6, 2023
BACKGROUND
Malignant schwannoma is a rare tumor in the peripheral nervous system, accounting for approximately 5% to 10% of systemic soft tissue sarcomas. Especially, malignant schwannoma occurring in the broad ligament of the uterus with hemophilic syndrome and bone marrow fibrosis is extremely rare in clinical practice. Here, we report the first case of an patient diagnosed with malignant peripheral nerve sheath tumor (MPNST) of the broad ligament of the uterus with hemophilic syndrome and bone marrow fibrosis, and share our reference clinical diagnosis and treatment experience.
CASE SUMMARY
A patient was diagnosed with MPNST of the uterus harboring hemophilic syndrome and bone marrow fibrosis. She received combination, and repeated imaging revealed further encountered rare complications (hemophilia syndrome and bone marrow fibrosis) after two cycles of chemotherapy. Thereafter, combined treatment with pazopanib, gemcitabine, and dacarbazine was initiated. Unfortunately, the patient succumbed to death at hospital after two weeks.
CONCLUSION
This report firstly provided reference clinical practice for a patient with MPNST of the uterus harboring hemophilic syndrome and bone marrow fibrosis. Our case raises a reminder about the tolerance and safety of combination therapy, especially in young women.
Core Tip: We reported an extremely rare case of malignant neurilemmoma of the broad ligament of the uterus. The patient was easily misdiagnosed at the beginning of diagnosis, and in the subsequent treatment process, the patient combined with rare hemophilic syndrome and bone marrow fibrosis, resulting in a very poor prognosis.
