Tang YY, Zhu GQ, Zheng ZJ, Yao LH, Wan ZX, Liang XH, Tang YL. Carcinosarcoma of the deep lobe of the parotid gland in the parapharyngeal region: A case report. World J Clin Cases 2023; 11(31): 7663-7672 [PMID: 38078142 DOI: 10.12998/wjcc.v11.i31.7663]
Corresponding Author of This Article
Ya-Ling Tang, PhD, Chief Doctor, Department of Oral Pathology, West China Hospital of Stomatology, Sichuan University, No. 14, Section 3, Renmin South Road, Chengdu 610041, Sichuan Province, China. tangyaling@scu.edu.cn
Research Domain of This Article
Pathology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Yue-Yang Tang, Zhi-Jian Zheng, Li-Hong Yao, Zi-Xin Wan, Ya-Ling Tang, Department of Oral Pathology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, Sichuan Province, China
Yue-Yang Tang, Gui-Quan Zhu, Zhi-Jian Zheng, Li-Hong Yao, Zi-Xin Wan, Xin-Hua Liang, Ya-Ling Tang, State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, Sichuan Province, China
Gui-Quan Zhu, Xin-Hua Liang, Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, Sichuan Province, China
Author contributions: Tang YY, Tang YL, and Liang XH determined the content of the article; Zheng ZJ, Yao LH, and Wan ZX performed paraffin sections and immunohistochemical sections; Tang YY and Zhu GQ collected the data; Tang YY and Tang YL analyzed the data and wrote the manuscript; all the authors read and approved the final manuscript.
Supported byScience and Technology Program of Sichuan Province, China, No. 2022YFS0289.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: All the authors have declared that they have no potential conflicts of interest and no financial relationships relevant to this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ya-Ling Tang, PhD, Chief Doctor, Department of Oral Pathology, West China Hospital of Stomatology, Sichuan University, No. 14, Section 3, Renmin South Road, Chengdu 610041, Sichuan Province, China. tangyaling@scu.edu.cn
Received: August 27, 2023 Peer-review started: August 27, 2023 First decision: September 26, 2023 Revised: October 7, 2023 Accepted: October 27, 2023 Article in press: October 27, 2023 Published online: November 6, 2023 Processing time: 71 Days and 5.5 Hours
Abstract
BACKGROUND
Salivary carcinosarcoma is an extremely rare tumor containing both malignant epithelial and mesenchymal constituents. This article reports a rare case of carcinosarcoma with salivary duct carcinoma and osteosarcoma as the tumor components. The clinicopathological characteristics, treatment, and prognosis are discussed in conjunction with the literature.
CASE SUMMARY
A 48-year-old man presented with a complaint of a mass in the right parotid region. Osteosarcoma was first considered for assessment by fine-needle aspiration cytology. Physical examination revealed a mass measuring approximately 4 cm × 3.5 cm × 3 cm. The mass, the whole lobe of the right parotid gland, and the right mandible were completely removed during surgery. Postoperative histopathology confirmed carcinosarcoma of the salivary gland.
CONCLUSION
A definite diagnosis of salivary gland carcinosarcoma can only be obtained after complete surgical resection.
Core Tip: Carcinosarcoma is a highly rare tumor with less than 100 reported cases, and only 13 cases of carcinosarcoma with an osteosarcoma component have been reported so far. Here, a rare case of carcinosarcoma with salivary duct carcinoma and osteosarcoma as the tumor components is reported. The clinicopathological characteristics, treatment, and prognosis are discussed in conjunction with the literature.
