Yu Y, Wang QQ, Jian L, Yang DC. Infrequent organ involvement in immunoglobulin G4-related prostate disease: A case report. World J Clin Cases 2023; 11(30): 7485-7491 [PMID: 37969446 DOI: 10.12998/wjcc.v11.i30.7485]
Corresponding Author of This Article
Yi Yu, Doctor, Department of Critical Care Medicine, Guangdong Provincial Hospital of Traditional Chinese Medicine, No. 55 Daxuecheng Neihuanxi Road, Guangzhou 510006, Guangdong Province, China. 1191922959@qq.com
Research Domain of This Article
Rheumatology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Oct 26, 2023; 11(30): 7485-7491 Published online Oct 26, 2023. doi: 10.12998/wjcc.v11.i30.7485
Infrequent organ involvement in immunoglobulin G4-related prostate disease: A case report
Yi Yu, Qian-Qian Wang, Li Jian, Deng-Can Yang
Yi Yu, Department of Critical Care Medicine, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou 510006, Guangdong Province, China
Qian-Qian Wang, Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510000, Guangdong Province, China
Li Jian, Department of Critical Care Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong Province, China
Deng-Can Yang, Anesthesiology Department, The Central Hospital of Shaoyang, Shaoyang 422000, Hunan Province, China
Author contributions: Yu Y and Wang QQ prepared the manuscript; Jian L collected material of this case; Yang DC critically reviewed the manuscript for important intellectual content and approved the final manuscript.
Supported bythe Guangdong Provincial Bureau of Traditional Chinese Medicine, No. 20222065; Science and Technology Planning Project of Guangdong Province of China, No. A2021100; and National Natural Science Foundation of China, No. 82104989.
Informed consent statement: Informed written consent was obtained from the patients for the publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yi Yu, Doctor, Department of Critical Care Medicine, Guangdong Provincial Hospital of Traditional Chinese Medicine, No. 55 Daxuecheng Neihuanxi Road, Guangzhou 510006, Guangdong Province, China. 1191922959@qq.com
Received: August 4, 2023 Peer-review started: August 4, 2023 First decision: August 24, 2023 Revised: August 26, 2023 Accepted: September 25, 2023 Article in press: September 25, 2023 Published online: October 26, 2023 Processing time: 82 Days and 1.6 Hours
Abstract
BACKGROUND
Immunoglobulin G4-related prostate disease (IgG4-RPD) characterized by a high count of IgG4-positive plasma cells has distinctive serological and radiological findings. Here we report a case of a patient who was successfully treated for IgG4-RPD, which manifested as frequent micturition, dysuric, and systemic lymphadenopathy.
CASE SUMMARY
The patient was a 33-year-old man who was referred to our hospital because of urinary tract symptoms that had persisted for 4 years. A physical examination revealed systemic lymphadenopathy and blood tests showed hyperglobulinemia with an IgG level of 18.90 g/L and an IgG4 level of 18.40 g/L. Computed tomography (CT) revealed bilateral lacrimal gland, right parotid gland and prostatic enlargement. Based on these findings, IgG4-RD was suspected, and further pathological examination and follow-up results showed expected results. Finally, the patient was diagnosed with IgG4-RPD based on clinical symptoms, pathological examination, therapeutic effects, and follow-up results. He received 50 mg oral prednisolone (the dose was gradually reduced and a low dose was used for long-term maintenance) in combination with cyclophosphamide 1.0 g via an intravenous drip for 6 mo. One year after the treatment was initiated, he was free of urinary or other complaints and his serum IgG4 level normalized.
CONCLUSION
In IgG4-RPD with severe urinary tract symptoms, radiological findings should be carefully examined. IgG4-RPD prognosis is good because the disease responds well to glucocorticoids. Furthermore, it is urgent for clinicians and pathologists to improve their understanding of IgG4-RPD.
Core Tip: Immunoglobulin G4-related prostate disease (IgG4-RPD) characterized by a high count of IgG4-positive plasma cells has distinctive serological and radiological findings. Here we report a case of a patient who was successfully treated for IgG4-RPD, which manifested as frequent micturition, dysuric, and systemic lymphadenopathy.
