Lee SJ, Song SY, Kim MK, Na HG, Bae CH, Kim YD, Choi YS. Complete response of metastatic BRAF V600-mutant anaplastic thyroid cancer following adjuvant dabrafenib and trametinib treatment: A case report. World J Clin Cases 2023; 11(27): 6664-6669 [PMID: 37900238 DOI: 10.12998/wjcc.v11.i27.6664]
Corresponding Author of This Article
Yoon Seok Choi, MD, PhD, Associate Professor, Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Yeungnam University, 170, Hyeonchung-ro, Nam-Gu, Daegu 42415, South Korea. choiys@ynu.ac.kr
Research Domain of This Article
Otorhinolaryngology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Sep 26, 2023; 11(27): 6664-6669 Published online Sep 26, 2023. doi: 10.12998/wjcc.v11.i27.6664
Complete response of metastatic BRAF V600-mutant anaplastic thyroid cancer following adjuvant dabrafenib and trametinib treatment: A case report
Sang Jae Lee, Si-Youn Song, Min Kyoung Kim, Hyung Gyun Na, Chang Hoon Bae, Yong-Dae Kim, Yoon Seok Choi
Sang Jae Lee, Si-Youn Song, Hyung Gyun Na, Chang Hoon Bae, Yong-Dae Kim, Yoon Seok Choi, Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Yeungnam University, Daegu 42415, South Korea
Min Kyoung Kim, Division of Hematology-Oncology, Department of Internal Medicine, College of Medicine, Yeungnam University, Daegu 42415, South Korea
Yong-Dae Kim, Regional Center for Respiratory Diseases, Yeungnam University Medical Center, Daegu 42415, South Korea
Author contributions: Lee SJ and Choi YS contributed to the conceptualization, data curation, and writing-review & editing; Bae CH and Na HG contributed to the formal analysis; Song SY and Choi YS contributed to the funding acquisition; Bae CH and Song SY contributed to the investigation; Kim MK and Choi YS contributed to the methodology and supervision; Kim YD and Bae CH contributed to the project administration; Lee SJ and Na HG contributed to the visualization; Lee SJ wrote the original draft.
Supported bythe 2023 Yeungnam University Research Grant.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors have nothing to disclose pertaining to this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yoon Seok Choi, MD, PhD, Associate Professor, Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Yeungnam University, 170, Hyeonchung-ro, Nam-Gu, Daegu 42415, South Korea. choiys@ynu.ac.kr
Received: July 26, 2023 Peer-review started: July 26, 2023 First decision: August 16, 2023 Revised: August 24, 2023 Accepted: August 31, 2023 Article in press: August 31, 2023 Published online: September 26, 2023
Abstract
BACKGROUND
Anaplastic thyroid cancer (ATC) is a rare but aggressive type of thyroid carcinoma. BRAF V600E-mutation, which is found in 10%-50% of ATCs, is associated with poor prognosis. A recent clinical trial reported a substantial clinical benefit of concomitant treatment of dabrafenib (BRAF inhibitor) and trametinib (MEK inhibitor) for treating BRAF V600E-mutant ATC. However, reports on patients with ATC treated with this regimen following surgery are lacking.
CASE SUMMARY
We report the case of a 63-year-old female patient diagnosed with BRAF V600E-mutant ATC. Following three surgeries—total thyroidectomy, total laryngectomy, and neck dissection—she was diagnosed with lung metastasis during follow-up. The metastatic ATC was successfully treated with dabrafenib and trametinib. The patient achieved a complete response at the 32-mo follow-up.
CONCLUSION
Adjuvant chemotherapy with dabrafenib plus trametinib is efficacious for treatment and prevention of recurrent ATC with BRAF mutation following surgery.
Core Tip: Anaplastic thyroid cancer (ATC) is a rare but aggressive type of thyroid carcinoma. The BRAF V600E-mutation, found in 10%-50% of ATCs, is associated with a poor prognosis. A recent clinical trial reported a substantial clinical benefit of dabrafenib (BRAF inhibitor) plus trametinib (MEK inhibitor) in treating BRAF V600E-mutant ATC. This report highlights the therapeutic potential of dabrafenib plus trametinib as an adjuvant chemotherapy to treat and prevent the recurrence of ATC confirmed with BRAF mutation following surgical resection.
