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World J Clin Cases. Sep 26, 2023; 11(27): 6318-6326
Published online Sep 26, 2023. doi: 10.12998/wjcc.v11.i27.6318
Characteristics of amino acid metabolism in colorectal cancer
Fen Xu, Hong-Liang Jiang, Wei-Wei Feng, Chen Fu, Jiang-Chang Zhou
Fen Xu, Hong-Liang Jiang, Wei-Wei Feng, Chen Fu, Jiang-Chang Zhou, Department of Gastroenterology, Xinhua Hospital Affiliated to Dalian University, Dalian 116000, Liaoning Province, China
Author contributions: Xu F wrote the paper; Jiang LH, Fu C, and Feng WW provided modification suggestions.
Conflict-of-interest statement: All the authors declare that they have no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jiang-Chang Zhou, MM, Chief Physician, Department of Gastroenterology, Xinhua Hospital Affiliated to Dalian University, No. 156 Viva District, Shahekou Street, Dalian 116000, Liaoning Province, China. endozhou@163.com
Received: May 9, 2023
Peer-review started: May 9, 2023
First decision: July 3, 2023
Revised: July 16, 2023
Accepted: August 18, 2023
Article in press: August 18, 2023
Published online: September 26, 2023
Processing time: 134 Days and 3.4 Hours
Abstract

In recent years, metabolomics research has become a hot spot in the screening and treatment of cancer. It is a popular technique for the quantitative characterization of small molecular compounds in biological cells, tissues, organs or organisms. Further study of the tumor revealed that amino acid changes may occur early in the tumor. The rapid growth and metabolism required for survival result in tumors exhibiting an increased demand for amino acids. An abundant supply of amino acids is important for cancer to maintain its proliferative driving force. Changes in amino acid metabolism can be used to screen malignant tumors and improve therapeutic outcomes. Therefore, it is particularly important to study the characteristics of amino acid metabolism in colorectal cancer. This article reviews several specific amino acid metabolism characteristics in colorectal cancer.

Keywords: Metabolomics; Amino acid metabolism; Colorectal cancer; Glutamine

Core Tip: In this article, we will delve into the characteristics of amino acid metabolism in colorectal cancer. Amino acid metabolism plays a crucial role in the occurrence and development of colorectal cancer. However, this topic is often overlooked and many people do not understand its importance. We will uncover this mystery to help better understand colorectal cancer and how to prevent and treat the disease by altering amino acid metabolism. Whether you are a medical professional or a casual individual with a deep interest in health, this article will provide a new perspective and in-depth understanding.