Zhu WF, Song SJ, Wei LW, Qiao JJ. Monkeypox presenting as a chancre-like rash: A case report. World J Clin Cases 2023; 11(25): 6025-6030 [PMID: 37727494 DOI: 10.12998/wjcc.v11.i25.6025]
Corresponding Author of This Article
Jian-Jun Qiao, MD, PhD, Doctor, Division of Dermatology, First Affiliated Hospital, Zhejiang University School of Medicine, No. 79 Qingchun Road, Hangzhou 310003, Zhejiang Province, China. qiaojianjun@zju.edu.cn
Research Domain of This Article
Infectious Diseases
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Wei-Fang Zhu, Lin-Wei Wei, Jian-Jun Qiao, Division of Dermatology, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, Zhejiang Province, China
Shu-Juan Song, Hangzhou Center of Disease Control and Prevention, Hangzhou Center of Disease Control and Prevention, Hangzhou 310000, Zhejiang Province, China
Author contributions: Zhu WF, Song SJ, and Wei LW contributed to manuscript writing and editing and data collection; Qiao JJ contributed to conceptualization and supervision; and all authors have read and approved the final manuscript.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jian-Jun Qiao, MD, PhD, Doctor, Division of Dermatology, First Affiliated Hospital, Zhejiang University School of Medicine, No. 79 Qingchun Road, Hangzhou 310003, Zhejiang Province, China. qiaojianjun@zju.edu.cn
Received: July 14, 2023 Peer-review started: July 14, 2023 First decision: August 2, 2023 Revised: August 4, 2023 Accepted: August 9, 2023 Article in press: August 9, 2023 Published online: September 6, 2023 Processing time: 48 Days and 20.7 Hours
Abstract
BACKGROUND
Since May 2022, outbreaks of monkeypox have occurred in many countries around the world, and several cases have been reported in China.
CASE SUMMARY
A 38-year-old man presented with a small, painless, shallow ulcer on the coronary groove for 8 d. One day after the rash appeared, the patient developed inguinal lymphadenopathy with fever. The patient had a history of male-male sexual activity and denied a recent history of travel abroad. Monkeypox virus was detected by quantitative polymerase chain reaction from the rash site and throat swab. Based on the epidemiological history, clinical manifestations and nucleic acid test results, the patient was diagnosed with monkeypox.
CONCLUSION
Monkeypox is an emerging infectious disease in China. Monkeypox presenting as a chancre-like rash is easily misdiagnosed. Diagnosis can be made based on exposure history, clinical manifestations and nucleic acid test results.
Core Tip: We reported an indigenous case of monkeypox transmitted by male-male sexual activity, suggesting the beginning of community transmission of monkeypox in the mainland of China. Monkeypox presenting as genital ulcers is easily misdiagnosed as chancre or other skin diseases. Clinicians should improve the awareness of monkeypox to avoid possible misdiagnosis and prevent the spread of monkeypox in the community.
