Stepanova OV, Fursa GA, Andretsova SS, Shishkina VS, Voronova AD, Chadin AV, Karsuntseva EK, Reshetov IV, Chekhonin VP. Prospects for the use of olfactory mucosa cells in bioprinting for the treatment of spinal cord injuries. World J Clin Cases 2023; 11(2): 322-331 [PMID: 36686356 DOI: 10.12998/wjcc.v11.i2.322]
Corresponding Author of This Article
Olga Vladislavovna Stepanova, PhD, Senior Scientist, Department of Basic and Applied Neurobiology, V.P. Serbsky National Medical Research Centre for Psychiatry and Narcology, 23 Kropotkinsky Lane, Moscow 119034, Russia. sms-34@yandex.ru
Research Domain of This Article
Neurosciences
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Jan 16, 2023; 11(2): 322-331 Published online Jan 16, 2023. doi: 10.12998/wjcc.v11.i2.322
Prospects for the use of olfactory mucosa cells in bioprinting for the treatment of spinal cord injuries
Olga Vladislavovna Stepanova, Grigorii Andreevich Fursa, Svetlana Sergeevna Andretsova, Valentina Sergeevna Shishkina, Anastasia Denisovna Voronova, Andrey Viktorovich Chadin, Ekaterina Konstantinovna Karsuntseva, Igor Vladimirovich Reshetov, Vladimir Pavlovich Chekhonin
Olga Vladislavovna Stepanova, Grigorii Andreevich Fursa, Svetlana Sergeevna Andretsova, Valentina Sergeevna Shishkina, Anastasia Denisovna Voronova, Andrey Viktorovich Chadin, Ekaterina Konstantinovna Karsuntseva, Vladimir Pavlovich Chekhonin, Department of Basic and Applied Neurobiology, V.P. Serbsky National Medical Research Center for Psychiatry and Narcology, Moscow 119034, Russia
Olga Vladislavovna Stepanova, Department of Neurohumoral and Immunological Research, National Medical Research Center of Cardiology, Moscow 121552, Russia
Svetlana Sergeevna Andretsova, Department of Biology, Moscow State University, Moscow 119991, Russia
Igor Vladimirovich Reshetov, Department of Plastic Surgery, I.M. Sechenov First Moscow State Medical University, Moscow 119435, Russia
Vladimir Pavlovich Chekhonin, Department of Medical Nanobiotechnologу, N.I. Pirogov Russian National Research Medical University, Moscow 117997, Russia
Author contributions: Stepanova OV designed the manuscript and drafted the abstract and introduction; Fursa GA drafted the chapters “4D bioprinting in the treatment for spinal cord injuries”and “Conclusions”; Andretsova SS drafted the chapter “Exogenous neurotrophin therapy”; Shishkina VS drafted the chapter “3D bioprinting in the therapy for spinal cords injury”; Voronova AD drafted the chapter “Neural stem cells/progenitor cells”; Chadin AV drafted the chapter “Ensheathing cells”; Karsuntseva EK drafted the chapter “Mesenchymal stem cells”; Reshetov IV contributed to the improvement and revision of the manuscript; Chekhonin VP provided the final approval of the version to be published.
Conflict-of-interest statement: There is no conflict of interest associated with any of the senior authors or other co-authors who contributed their efforts to this manuscript.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Olga Vladislavovna Stepanova, PhD, Senior Scientist, Department of Basic and Applied Neurobiology, V.P. Serbsky National Medical Research Centre for Psychiatry and Narcology, 23 Kropotkinsky Lane, Moscow 119034, Russia. sms-34@yandex.ru
Received: September 19, 2022 Peer-review started: September 19, 2022 First decision: November 14, 2022 Revised: November 28, 2022 Accepted: January 5, 2023 Article in press: January 5, 2023 Published online: January 16, 2023 Processing time: 114 Days and 17.3 Hours
Abstract
The review focuses on the most important areas of cell therapy for spinal cord injuries. Olfactory mucosa cells are promising for transplantation. Obtaining these cells is safe for patients. The use of olfactory mucosa cells is effective in restoring motor function due to the remyelination and regeneration of axons after spinal cord injuries. These cells express neurotrophic factors that play an important role in the functional recovery of nerve tissue after spinal cord injuries. In addition, it is possible to increase the content of neurotrophic factors, at the site of injury, exogenously by the direct injection of neurotrophic factors or their delivery using gene therapy. The advantages of olfactory mucosa cells, in combination with neurotrophic factors, open up wide possibilities for their application in three-dimensional and four-dimensional bioprinting technology treating spinal cord injuries.
Core Tip: The development of an optimal strategy for the treatment of spinal cord injuries is a relevant and topical issue in modern medicine. Olfactory mucosa cells and neurotrophic factors showed their effectiveness in transplantation into the area of the injured spinal cord. In this review, the authors discuss the possibility of their application in four-dimensional bioprinting to create transplants that would have a complex impact on the transplant-mediated repair of the damaged area of the spinal cord.
