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World J Clin Cases. Jan 16, 2023; 11(2): 316-321
Published online Jan 16, 2023. doi: 10.12998/wjcc.v11.i2.316
Liver transplantation amidst the COVID-19 era: Our center’s experience
Shrouq Khazaaleh, Zoilo Karim Suarez, Mohammad Alomari, Mamoon Ur Rashid, Armaan Handa, Adalberto Jose Gonzalez, Xaralambos Bobby Zervos, Nikhil Kapila
Shrouq Khazaaleh, Department of Internal Medicine, Cleveland Clinic Fairview Hospital, Cleveland, OH 44126, United States
Zoilo Karim Suarez, Department of Internal Medicine, Florida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, FL 33431, United States
Mohammad Alomari, Mamoon Ur Rashid, Adalberto Jose Gonzalez, Xaralambos Bobby Zervos, Nikhil Kapila, Department of Gastroenterology and Hepatology, Cleveland Clinic Florida, Weston, FL 33331, United States
Armaan Handa, Royal College of Surgeons, Dublin 11111, United Kingdom
Author contributions: Khazaaleh S, Suarez ZK, and Alomari M contributed to data collection, the literature search, and manuscript writing; Rashid MU and Handa A contributed to the literature search and manuscript writing; Gonzalez AJ, Zervos XB, and Kapila N contributed to the interpretation and critical revision of the manuscript for important intellectual content.
Conflict-of-interest statement: There was no external funding used in preparing our manuscript. Our authors have no financial relationship to the work, receive no government or company grants or research support, and are neither employees nor consultants for a pharmaceutical company. We are not stockholders of a pharmaceutical company or members of a speaker’s bureau.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Nikhil Kapila, MD, Assistant Professor, Department of Gastroenterology and Hepatology, Cleveland Clinic Florida, 2950 Cleveland Clinic Blvd. Weston, FL 33331, United States. kapilan@ccf.org
Received: September 22, 2022
Peer-review started: September 22, 2022
First decision: November 22, 2022
Revised: December 8, 2022
Accepted: January 5, 2023
Article in press: January 5, 2023
Published online: January 16, 2023
Abstract

Coronavirus disease 2019 significantly impacted the liver transplant process worldwide. Consequently, it brought significant challenges and limitations to transplant policies and organ allocation forcing liver transplant centers to adjust their protocols to ensure maximum benefit and avoid harm to their patients. Our center, like many others, was obliged to adapt to the challenges. This paper provided an overview of the effects of coronavirus disease 2019 on liver transplantations and detailed our center’s experience and efforts during this unprecedented pandemic to serve as a guide for future public health crises.

Keywords: COVID-19, Liver transplantation, Immunosuppression, Experience, Mortality

Core Tip: The coronavirus disease 2019 pandemic gave rise to an exceptional situation for liver transplantation (LT) around the world, initially leading to a decline in LT followed by a rapid recovery. This robust response resulted from extensive efforts by various LT centers to offset these challenges in addition to emerging evidence and the provision of appropriate guidelines from major LT societies. It is of the utmost importance to share experiences among LT centers to improve outcomes and reduce graft loss.