Published online Jun 16, 2023. doi: 10.12998/wjcc.v11.i17.4179
Peer-review started: April 5, 2023
First decision: April 28, 2023
Revised: May 6, 2023
Accepted: May 19, 2023
Article in press: May 19, 2023
Published online: June 16, 2023
Processing time: 67 Days and 19.4 Hours
Patients with chronic inflammatory disorders are at a higher risk of developing aggressive Merkel cell carcinoma (MCC). Diabetes is a common chronic inflammatory disease that is possibly associated with MCC; however, there are still no reports on the association between hepatitis B virus (HBV) infection and MCC. Whether there is an association between these three diseases and the specific mechanisms behind their effects is worth further research in the future.
We herein report a rare case of MCC with extracutaneous and nodal invasion in an Asian individual with type 2 diabetes mellitus and chronic HBV infection, but no immunosuppression or other malignancies. Such cases are uncommon and have rarely been reported in the literature. A 56-year-old Asian male presented with a significant mass on his right cheek and underwent extensive resection combined with parotidectomy, neck lymphadenectomy, and split-thickness skin grafting. Based on the histopathological findings, a diagnosis of MCC involving the adipose tissue, muscle, nerve, and parotid gland with lymphovascular invasion was made. Subsequently, he received radiotherapy with no adverse reactions.
MCC is a rare, aggressive skin cancer with frequent local recurrence, nodal inv
Core Tip: Merkel cell carcinoma in a person of the yellow race with type 2 diabetes mellitus and chronic hepatitis B virus infection but no immunosuppression or other malignancies is a rare case and has rarely been reported in the literature.