Michoglou K, Ravinthiranathan A, San Ti S, Dolly S, Thillai K. Pancreatic cancer and depression. World J Clin Cases 2023; 11(12): 2631-2636 [PMID: 37214569 DOI: 10.12998/wjcc.v11.i12.2631]
Corresponding Author of This Article
Kiruthikah Thillai, Doctor, FRCP, MBBS, MD, MRCP, PhD, Doctor, Department of Oncology, Guy's and St Thomas' NHS Foundation Trust, Great Maze Pond, London SE1 9RT, United Kingdom. kiruthikah.thillai@gstt.nhs.uk
Research Domain of This Article
Oncology
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Kalliopi Michoglou, Amsajini Ravinthiranathan, Saw San Ti, Saoirse Dolly, Kiruthikah Thillai, Department of Oncology, Guy's and St Thomas' NHS Foundation Trust, London Se1 9RT, United Kingdom
Author contributions: All authors contributed equally to the writing of this article; all authors read and approved the final version of this paper.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Kiruthikah Thillai, Doctor, FRCP, MBBS, MD, MRCP, PhD, Doctor, Department of Oncology, Guy's and St Thomas' NHS Foundation Trust, Great Maze Pond, London SE1 9RT, United Kingdom. kiruthikah.thillai@gstt.nhs.uk
Received: November 19, 2022 Peer-review started: November 19, 2022 First decision: December 10, 2022 Revised: February 10, 2023 Accepted: March 27, 2023 Article in press: March 27, 2023 Published online: April 26, 2023
Abstract
Pancreatic cancer is a highly devastating disease with high mortality rates. Even patients who undergo potential curative surgery have a high risk for recurrence. The incidence of depression and anxiety are higher in patients with cancer than the general population. However, patients with pancreatic cancer are at most of risk of both depression and anxiety and there seems to be a biological link. In some patients, depression seems to be a precursor to pancreatic cancer. In this article we discuss the biological link between depression anxiety and hepatobiliary malignancies and discuss treatment strategies.
Core Tip: Pancreatic cancer has one of the highest mortality rates of all malignancies. There is a strong correlation between pancreatic cancer and depression and we discuss the evidence behind this.
