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©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jan 6, 2023; 11(1): 7-16
Published online Jan 6, 2023. doi: 10.12998/wjcc.v11.i1.7
Published online Jan 6, 2023. doi: 10.12998/wjcc.v11.i1.7
Postoperative diarrhea in Crohn’s disease: Pathogenesis, diagnosis, and therapy
En-Hao Wu, Zhen Guo, Wei-Ming Zhu, Department of General Surgery, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, Jiangsu Province, China
Author contributions: All authors have read and approve the final manuscript.
Supported by Jiangsu Provincial Health Commission , No. M2021013 ; and the Science Foundation of Jinling Hospital , No.YYMS2021035 .
Conflict-of-interest statement: All the authors declare no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zhen Guo, MD, PhD, Professor, Department of General Surgery, Affiliated Jinling Hospital, Medical School of Nanjing University, No. 305 East Zhongshan Road, Nanjing 210002, Jiangsu Province, China. guozhi0809@sina.com
Received: November 13, 2022
Peer-review started: November 13, 2022
First decision: November 23, 2022
Revised: December 8, 2022
Accepted: December 23, 2022
Article in press: December 23, 2022
Published online: January 6, 2023
Peer-review started: November 13, 2022
First decision: November 23, 2022
Revised: December 8, 2022
Accepted: December 23, 2022
Article in press: December 23, 2022
Published online: January 6, 2023
Abstract
Diarrhea is a frequent symptom in postoperative patients with Crohn’s diseases (CD), and several different mechanisms likely account for postoperative diarrhea in CD. A targeted strategy based on a comprehensive understanding of postoperative diarrhea is helpful for better postoperative recovery.
Keywords: Postoperative diarrhea, Crohn’s disease, Intestinal resection, Bile acid malabsorption, Treatment
Core Tip: Postoperative diarrhea can be divided into inflammatory and noninflammatory diarrhea. Because of the characteristics of Crohn's disease (CD), postoperative diarrhea is clinically very common; however, not much attention is paid to it. In this article, we review the causes, diagnoses, and treatments of postoperative diarrhea in CD.