Hsiao TH, Wu CC, Tseng HH, Chen JH. Synchronous but separate neuroendocrine tumor and high-grade dysplasia/adenoma of the gall bladder: A case report. World J Clin Cases 2022; 10(7): 2322-2329 [PMID: 35321155 DOI: 10.12998/wjcc.v10.i7.2322]
Corresponding Author of This Article
Jiann-Hwa Chen, MD, Director, Division of Gastroenterology and Hepatology; Department of Internal Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, No. 289 Chien Kao Road, Xin-dien, New Taipei City 231, Taiwan. jhctylci@gmail.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Tsung-Hsien Hsiao, Division of Gastroenterology and Hepatology, Taipei Tzu Chi Hospital, New Taipei City 231, Taiwan
Chao-Chuan Wu, Department of Surgery, Taipei Tzu Chi Hospital, New Taipei City 231, Taiwan
Hui-Hwa Tseng, Department of Pathology, Taipei Tzu Chi Hospital, New Taipei City 231, Taiwan
Jiann-Hwa Chen, Division of Gastroenterology and Hepatology; Department of Internal Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City 231, Taiwan
Author contributions: Hsiao TH collected the data for the manuscript; Wu CC performed the surgery; Tseng HH conducted the pathological evaluation; Chen JH was responsible for the writing and revision of the manuscript.
Informed consent statement: Consent for surgery was obtained from the patient herself, who also consented to our publication of her anonymized case.
Conflict-of-interest statement: The authors declare having no conflicts of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jiann-Hwa Chen, MD, Director, Division of Gastroenterology and Hepatology; Department of Internal Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, No. 289 Chien Kao Road, Xin-dien, New Taipei City 231, Taiwan. jhctylci@gmail.com
Received: October 5, 2021 Peer-review started: October 5, 2021 First decision: November 8, 2021 Revised: November 22, 2021 Accepted: January 19, 2022 Article in press: January 19, 2022 Published online: March 6, 2022 Processing time: 147 Days and 14.6 Hours
Abstract
BACKGROUND
Gall bladder neuroendocrine tumors (GB-NETs) are rare, accounting for less than 0.5% of all NETs. They usually lack specific symptoms and are difficult to diagnose preoperatively. In most cases, GB-NETs are incidentally found after cholecystectomy for large polyps or cholelithiasis, causing acute or chronic cholecystitis. The coexistence of GB-NET and GB adenocarcinoma is very rare.
CASE SUMMARY
We report a case of synchronous but separate GB-NET and adenoma with high-grade dysplasia in a patient who had undergone surgery for a progressively growing GB polypoid lesion. To the best of our knowledge, simultaneous separation of NETs and cancer in the GB has not been reported.
CONCLUSION
Coexistent GB carcinoid tumor and adenocarcinoma is rare. A surveillance program is needed for these large GB polyps.
Core Tip: Gall bladder (GB) polyps are commonly found in routine abdominal ultrasound examination; however, GB carcinoid tumors are rare, especially with the coexistence of an adenocarcinoma component. Physicians should be aware of rapidly growing GB polyps; in those cases, imaging examinations such as contrast-enhanced computed tomography and magnetic resonance imaging are needed to elucidate the nature of these lesions.
