Li Y, Xie YD, He SJ, Hu JM, Li ZS, Qu SH. Breast and dorsal spine relapse of granulocytic sarcoma after allogeneic stem cell transplantation for acute myelomonocytic leukemia: A case report. World J Clin Cases 2022; 10(7): 2315-2321 [PMID: 35321182 DOI: 10.12998/wjcc.v10.i7.2315]
Corresponding Author of This Article
Shao-Hua Qu, MD, PhD, Doctor, Department of Breast Surgery, The First Affiliated Hospital of Jinan University, No. 613 Huangpu Road West, guangzhou 510763, Guangdong Province, China. qushaohua2009@163.com
Research Domain of This Article
Oncology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Yuan Li, Yu-De Xie, Jia-Mei Hu, Zhi-Sheng Li, Shao-Hua Qu, Department of Breast Surgery, The First Affiliated Hospital of Jinan University, Guangzhou 510630, Guangdong Province, China
Shao-Jie He, Department of Orthopaedics, The First Affiliated Hospital of Jinan University, Guangzhou 510630, Guangdong Province, China
Author contributions: Li Y and He SJ contributed to manuscript drafting; Xie YD, Hu JM and Li ZS provided patient information and collected the data; Qu SH was responsible for the revision of the manuscript; all authors contributed to the article and approved the final manuscript.
Supported byYouth Science Foundation of National Natural Science Foundation of China, No. 81702598; The Science Foundation of Guangdong Province, No. 2017A030313803; The Science and Technology Program of Guangzhou, No. 201804010011.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflicting interests.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Shao-Hua Qu, MD, PhD, Doctor, Department of Breast Surgery, The First Affiliated Hospital of Jinan University, No. 613 Huangpu Road West, guangzhou 510763, Guangdong Province, China. qushaohua2009@163.com
Received: October 9, 2021 Peer-review started: October 9, 2021 First decision: October 27, 2021 Revised: October 30, 2021 Accepted: January 25, 2022 Article in press: January 25, 2022 Published online: March 6, 2022 Processing time: 144 Days and 2.7 Hours
Abstract
BACKGROUND
Granulocytic sarcoma (GS) is a rare malignant tumor, and relapse is even rarer in the breast and dorsal spine following allogeneic hematopoietic stem cell transplantation. Currently, a standard treatment regimen is not available.
CASE SUMMARY
A rare case of GS of the right breast and dorsal spine after complete remission of acute myelogenous leukemia is reported here. A 55-year-old female patient presented with a palpable, growing, painless lump as well as worsening dorsal compressive myelopathy. She had a history of acute myelomonocytic leukemia (AML M4) and achieved complete remission after chemotherapy following allogeneic hematopoietic stem cell transplantation. Imaging examinations showed the breast lump and C7-T1 epidural masses suspected of malignancy. Histologic results were compatible with GS in both the right breast and dorsal spine, which were considered extramedullary relapse of the AML treated 4 years earlier.
CONCLUSION
A rare case of GS relapse following allogeneic hematopoietic stem cell transplantation and guidelines for treatment are discussed.
Core Tip: Granulocytic sarcoma is unusual, and relapse in the breast and dorsal spine after complete remission of acute myeloid leukemia is even rarer. Imaging examinations and histopathologic examinations are essential for the final diagnosis. We reviewed the associated literature and found that the survival rate of the relapse is poor. At present, more prospective studies and clinical trials are needed to standardize its treatment.
