Published online Mar 6, 2022. doi: 10.12998/wjcc.v10.i7.2222
Peer-review started: July 3, 2021
First decision: July 14, 2021
Revised: July 15, 2021
Accepted: January 22, 2022
Article in press: January 22, 2022
Published online: March 6, 2022
Processing time: 241 Days and 19.7 Hours
Primary hepatic neuroendocrine neoplasm (NEN) is a rare condition, and it is difficult to differentiate between primary and metastatic hepatic NENs. Herein, we report a case of primary hepatic NEN that initially mimicked a hemangioma but showed a gradual increase in size on long-term careful observation.
A 47-year-old woman was incidentally diagnosed with a 12-mm liver mass, suspected to be a hemangioma. Since then, regular follow-up had been carried out. Ten years later, she was referred to our institute due to the tumor (located in segment 4) having increased to 20 mm. Several imaging studies depicted no apparent extrahepatic lesion. Positron emission tomography (PET)/computed tomography exhibited significant accumulation in the mass lesion, which made us consider the possibility of malignancy. Left hepatectomy was performed. The histopathological diagnosis was neuroendocrine tumor grade 2, with somatostatin receptor 2a/5 positivity. Postoperative somatostatin receptor scintigraphy (SRS) showed no other site, leading to the diagnosis of NEN of primary hepatic origin. The gradual growth of the hepatic NEN over 10 years suggested that it was likely to be a primary liver tumor.
In this case, positivity on PET and postoperative SRS may have helped determine whether the tumor was primary or metastatic.
Core Tip: The clinical diagnosis of primary hepatic neuroendocrine neoplasm (NEN) remains challenging due to its rarity and difficulty in differentiating between primary and metastatic NENs. We present a case of primary hepatic NEN that presented with exceedingly gradual growth over 10 years, initially mimicking a hemangioma. Close preoperative observation, positron emission tomography findings, and postoperative somatostatin receptor scintigraphy findings greatly contributed to the final diagnosis. This case highlights the importance of close preoperative observations of NENs. In addition, the clinical usefulness of these modalities for correct diagnosis has been suggested, although regular postoperative follow-up is required.