Huang YX, He GX, Zhang WJ, Li BW, Weng HX, Luo WC. Quetiapine-related acute lung injury: A case report. World J Clin Cases 2022; 10(7): 2216-2221 [PMID: 35321186 DOI: 10.12998/wjcc.v10.i7.2216]
Corresponding Author of This Article
Yi-Xia Huang, BMed, Doctor, Intensive Care Unit, The Third Affiliated Hospital, Wenzhou Medical University, No. 108 Wansong Road, Ruian 330381, Zhejiang Province, China. 378206482@qq.com
Research Domain of This Article
Respiratory System
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Yi-Xia Huang, Guo-Xin He, Wen-Jing Zhang, Bo-Wu Li, Hai-Xu Weng, Wen-Chao Luo, Intensive Care Unit, The Third Affiliated Hospital, Wenzhou Medical University, Ruian 330381, Zhejiang Province, China
Author contributions: Huang YX and He GX were responsible for the conception and design; Huang YX and Zhang WJ were responsible for manuscript writing and revision; Li BW, Weng HX, and Luo WC participated in the data analysis; and all authors read and approved the final manuscript.
Informed consent statement: Written informed consent was obtained from the patient for publication of this case report.
Conflict-of-interest statement: The authors report no conflicts of interest in this work.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yi-Xia Huang, BMed, Doctor, Intensive Care Unit, The Third Affiliated Hospital, Wenzhou Medical University, No. 108 Wansong Road, Ruian 330381, Zhejiang Province, China. 378206482@qq.com
Received: March 24, 2021 Peer-review started: March 24, 2021 First decision: October 16, 2021 Revised: October 27, 2021 Accepted: January 22, 2022 Article in press: January 22, 2022 Published online: March 6, 2022 Processing time: 342 Days and 21.6 Hours
Abstract
BACKGROUND
Quetiapine, known as a non-classical antipsychotic drug, is frequently used for the treatment of mental diseases, such as schizophrenia, bipolar disorder, and major depressive disorder. Acute lung injury, a rarely reported side effect of quetiapine, is described in this case report.
CASE SUMMARY
Due to terminal delirium, a 66-year-old man took a large dose of quetiapine and then developed severe pulmonary disease. His symptoms were not resolved after routine treatment, such as antibiotics, diuretic, and supportive therapies. Quetiapine-related acute lung injury was therefore suspected and hormonal therapy was initiated. Subsequently, his symptoms were alleviated and the radiological results improved dramatically.
CONCLUSION
Our findings in the present report highlight a potential adverse effect of quetiapine, drug-related acute lung injury, which deserves awareness in clinical practice.
Core Tip: Quetiapine is a non-classic antipsychotic drug. Acute lung injury, a rarely reported side effect of quetiapine, is described in this case report. Common etiologies were ruled out when the patient’s symptoms were not resolved after routine treatment. Finally, quetiapine-related acute lung injury was suspected and hormonal therapy was initiated. The patient’s symptoms were alleviated and the radiological results improved. The case report highlights this potential adverse effect of quetiapine, which deserves more awareness in clinical practice.
