Duan HZ, Liu JJ, Zhang XJ, Zhang J, Yu AY. Multiple miscarriages in a female patient with two-chambered heart and situs inversus totalis: A case report . World J Clin Cases 2022; 10(4): 1333-1340 [PMID: 35211567 DOI: 10.12998/wjcc.v10.i4.1333]
Corresponding Author of This Article
An-Yong Yu, MD, Doctor, Department of Emergency Medicine, Affiliated Hospital of Zunyi Medical University, No. 149 Dalian Road, Huichuan District, Zunyi 563000, Guizhou Province, China. anyongyu0851@126.com
Research Domain of This Article
Obstetrics & Gynecology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Feb 6, 2022; 10(4): 1333-1340 Published online Feb 6, 2022. doi: 10.12998/wjcc.v10.i4.1333
Multiple miscarriages in a female patient with two-chambered heart and situs inversus totalis: A case report
Hai-Zhen Duan, Jia-Ji Liu, Xiao-Jun Zhang, Ji Zhang, An-Yong Yu
Hai-Zhen Duan, Xiao-Jun Zhang, Ji Zhang, An-Yong Yu, Department of Emergency Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi 563000, Guizhou Province, China
Jia-Ji Liu, Department of Radiology, the First People's Hospital of Zunyi, Zunyi 563000, Guizhou Province, China
Author contributions: Duan HZ and Yu AY carried out the studies, participated in collecting data, and drafted the manuscript; Liu JJ participated in collecting data; Zhang XJ and Zhang J helped to draft the manuscript; all authors read and approved the final manuscript.
Supported byChinese Ministry of Education (No. 2020-39) and Zunyi Science and Technology Project, No. Zunshi Kehe HZ (2020) 246.
Informed consent statement: Informed written consent was obtained from the patient for publication of this case report and accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: An-Yong Yu, MD, Doctor, Department of Emergency Medicine, Affiliated Hospital of Zunyi Medical University, No. 149 Dalian Road, Huichuan District, Zunyi 563000, Guizhou Province, China. anyongyu0851@126.com
Received: August 17, 2021 Peer-review started: August 17, 2021 First decision: November 2, 2021 Revised: November 17, 2021 Accepted: January 22, 2021 Article in press: December 22, 2021 Published online: February 6, 2022
Abstract
BACKGROUND
Single atrium with single ventricle, or a two-chambered heart, is an extremely rare congenital malformation. Few cases with two-chambered heart surviving to adulthood have been reported.
CASE SUMMARY
We reported an adult female patient with a two-chambered heart and situs inversus totalis accompanied by multiple pregnancies and abortions. Magnetic resonance imaging detected a two-chambered heart. B-ultrasound-guided uterine aspiration was performed to absorb 8 g and 10 g of organized villus and decidual tissues, respectively, with a small amount of bleeding. Postoperatively, cyanosis and fatigue-induced shortness of breath were gradually relieved. The patient has currently outlived all similar cases reported so far.
CONCLUSION
Hemodynamic changes in pregnant women with two-chambered heart impaired cardiac function, responsible for hypoperfusion and miscarriage.
Core tip: The two-chambered heart is characterized by common atrioventricular valves connecting the single atrium and single ventricle. Most patients with two-chambered heart die before or around 20 years of age. Pregnancy in these patients is very rare, and it is unknown how the disease might affect the pregnancy outcome. The current patient with a two-chambered heart has lived longer than all similar cases reported to date, and has remained active. The case reported here was accompanied by eight adverse pregnancies and early abortions. Pregnancy may negatively affect cardiac function in patients with a two-chambered heart, and poor heart function could lead to uterine hypoperfusion and subsequent miscarriage.
