Jang HR, Lim KH, Lee K. Primary central nervous system lymphoma presenting as a single choroidal lesion mimicking metastasis: A case report. World J Clin Cases 2022; 10(4): 1291-1295 [PMID: 35211562 DOI: 10.12998/wjcc.v10.i4.1291]
Corresponding Author of This Article
Kyu-Hyoung Lim, Doctor, MD, PhD, Associate Professor, Department of Internal Medicine, Kangwon National University Hospital, Kangwon National University School of Medicine, 156 Baengnyeong-ro, Chuncheon 24289, South Korea. kyuhyoung.lim@gmail.com
Research Domain of This Article
Oncology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Feb 6, 2022; 10(4): 1291-1295 Published online Feb 6, 2022. doi: 10.12998/wjcc.v10.i4.1291
Primary central nervous system lymphoma presenting as a single choroidal lesion mimicking metastasis: A case report
Hee Ryeong Jang, Kyu-Hyoung Lim, Kyungyul Lee
Hee Ryeong Jang, Kyu-Hyoung Lim, Department of Internal Medicine, Kangwon National University Hospital, Kangwon National University School of Medicine, Chuncheon 24289, South Korea
Kyungyul Lee, Department of Pathology, Kangwon National University Hospital, Kangwon National University School of Medicine, Chuncheon 24289, South Korea
Author contributions: All authors contributed to the study conception and design; Material preparation and data collection and analysis were performed by Lim KH, Hee Ryeong Jang, and Kyung Yul Lee; The first draft of the manuscript was written by Hee Ryeong Jang; and all authors commented on the previous versions of the manuscript; all authors read and approved the final manuscript.
Informed consent statement: The need for patient consent for publication of this report was waived by the Institutional Review Board of Kangwon National University Hospital (IRB No. KNUH-2021-02-020).
Conflict-of-interest statement: All authors declare that there is no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Kyu-Hyoung Lim, Doctor, MD, PhD, Associate Professor, Department of Internal Medicine, Kangwon National University Hospital, Kangwon National University School of Medicine, 156 Baengnyeong-ro, Chuncheon 24289, South Korea. kyuhyoung.lim@gmail.com
Received: July 26, 2021 Peer-review started: July 26, 2021 First decision: October 22, 2021 Revised: November 4, 2021 Accepted: December 22, 2021 Article in press: December 22, 2021 Published online: February 6, 2022 Processing time: 182 Days and 3.3 Hours
Abstract
BACKGROUND
Primary choroidal lymphoma is usually an indolent B-cell lymphoma and rarely progresses to extraocular sites. Herein, we report a case of primary choroidal lymphoma diagnosed as diffuse large B-cell lymphoma (DLBL), which progressed to the brain parenchyma after 4 mo.
CASE SUMMARY
A 78-year-old man presented with diminution of vision in his right eye. A choroidal lesion suspected of metastatic lesion was observed in the right eye by ophthalmologic examination. To discover the primary tumor, imaging investigations were performed but no malignant lesion was detected. After 4 mo, the patient returned to the clinic presenting with neurological symptoms. Brain magnetic resonance imaging revealed an abnormal contrast-enhancing mass in the left cerebellum. A stereotactic biopsy was performed, and DLBL was confirmed. The patient received the high dose methotrexate-based chemotherapy and he achieved complete remission.
CONCLUSION
Primary choroidal lymphoma is usually known to have a benign clinical course without systemic involvement. We present a rare case of primary choroidal lymphoma diagnosed as DLBL that progressed to the brain parenchyma within months.
Core Tip: Primary choroidal lymphoma is a rare subset of primary intraocular lymphoma and shows a benign clinical course with no systemic involvement. Our case report involves a primary choroidal lymphoma demonstrating rare extraocular progression within months.
