Published online Nov 6, 2022. doi: 10.12998/wjcc.v10.i31.11500
Peer-review started: May 13, 2022
First decision: August 4, 2022
Revised: August 9, 2022
Accepted: October 9, 2022
Article in press: October 9, 2022
Published online: November 6, 2022
Processing time: 166 Days and 15 Hours
Polycystic kidney disease (PKD) is a genetic disorder characterized by the growth of numerous cysts within the kidneys. Disease progress of some patients often occurs at the early stage. Thus, managing and controlling disease progress is important to slow the kidney function decline especially for the patient with other disorders.
One 80-year-old male autosomal dominant polycystic kidney disease (ADPKD) patient with chronic kidney disease and other clinical disorders was treated with tolvaptan and edoxaban. Estimated glomerular filtration rate, creatinine and uric acid were monitored during the treatment. In addition, the whole exome sequencing was performed to screen ADPKD genetic variants. The kidney function decline was prevented after using tolvaptan and edoxaban treatment and in the meantime, a venous thromboembolism was removed and leg and pedal edema were alleviated. One mutation c.10102G>A /p.D3368N in the PKD1 gene was identified.
Tolvaptan combined with edoxaban administration could delay kidney function decline and eliminate the edema caused by the thromboembolism.
Core Tip: Autosomal dominant polycystic kidney disease is a genetic and heritable kidney disease. It appears with cyst formation and growth, kidney enlargement and eventually leads to end stage renal disease. Some patients with severe polycystic kidney disease and end stage kidney disease have been treated with nephrectomy and early dialysis therapy, however, the life quality of these autosomal dominant polycystic kidney disease (ADPKD) patients declines due to the above treatment. In this case report, tolvaptan combined with edoxaban administration improved kidney function for one elderly ADPKD patient while avoiding the decreased life quality from nephrectomy or dialysis therapy.