Maksimaityte V, Reivytyte R, Milaknyte G, Mickys U, Razanskiene G, Stundys D, Kazenaite E, Valantinas J, Stundiene I. Metastatic multifocal melanoma of multiple organ systems: A case report. World J Clin Cases 2022; 10(28): 10136-10145 [PMID: 36246820 DOI: 10.12998/wjcc.v10.i28.10136]
Corresponding Author of This Article
Vaidota Maksimaityte, MD, Doctor, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, 3 Universiteto Street, Vilnius 01513, Lithuania. vaidamaksimaityte@gmail.com
Research Domain of This Article
Oncology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Oct 6, 2022; 10(28): 10136-10145 Published online Oct 6, 2022. doi: 10.12998/wjcc.v10.i28.10136
Metastatic multifocal melanoma of multiple organ systems: A case report
Vaidota Maksimaityte, Rosita Reivytyte, Gabriele Milaknyte, Ugnius Mickys, Gintare Razanskiene, Domantas Stundys, Edita Kazenaite, Jonas Valantinas, Ieva Stundiene
Vaidota Maksimaityte, Gabriele Milaknyte, Domantas Stundys, Edita Kazenaite, Jonas Valantinas, Ieva Stundiene, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius 01513, Lithuania
Rosita Reivytyte, Faculty of Medicine, Vilnius University, Vilnius 01513, Lithuania
Ugnius Mickys, Gintare Razanskiene, Institute of Biomedical Sciences, Faculty of Medicine, Vilnius University, Vilnius 01513, Lithuania
Author contributions: Maksimaityte V, Reivytyte R, Milaknyte G performed patient’s data extraction and literature analysis; Stundiene I was the gastroenterologist who followed up the patient; Maksimaityte V, Reivytyte R, Stundys D, wrote the manuscript; Mickys U, Razanskiene G Kazenaite E, Valantinas J, Stundiene I revised the manuscript for important intellectual content; all authors approved the final version of the manuscript to be submitted.
Informed consent statement: Informed written consent was obtained from the patient.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Vaidota Maksimaityte, MD, Doctor, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, 3 Universiteto Street, Vilnius 01513, Lithuania. vaidamaksimaityte@gmail.com
Received: February 8, 2022 Peer-review started: February 8, 2022 First decision: March 23, 2022 Revised: April 5, 2022 Accepted: July 27, 2022 Article in press: July 27, 2022 Published online: October 6, 2022 Processing time: 230 Days and 22.5 Hours
Abstract
BACKGROUND
Malignant melanoma is becoming more common among middle-aged individuals all over the world. Melanoma metastasis can be found in various organs, although metastases to the spleen and stomach are rare. Herein we present a rare metastatic multifocal melanoma, clinically and histologically mimicking lymphoma, with metastases of multiple organs.
CASE SUMMARY
A 46-year-old Caucasian male with a history of nodular cutaneous malignant melanoma was presented with nausea, general weakness, shortness of breath, abdominal enlargement, and night sweating. The abdominal ultrasound revealed enlarged liver and spleen with multiple lesions. Computed tomography demonstrated multiple lesions in the lungs, liver, spleen, subcutaneous tissue, bones and a pathological lymphadenopathy of the neck. Trephine biopsy and the biopsy from the enlarged lymph node were taken. Tumor cells showed diffuse or partial positivity for melanocytic markers, such as microphthalmia - associated transcription factor, S100, HMB45 and Melan-A. The tumor harbored BRAF V600E mutation, demonstrated by immunohistochemical labelling for BRAF V600E and detected by real-time polymerase chain reaction test. Having combined all the findings, a diagnosis was made of a metastatic multifocal melanoma of the stomach, duodenum, liver, spleen, lungs, lymph nodes and bones. The patient refused treatment and died a week later.
CONCLUSION
This case report highlights the clinical relevance of rare metastatic multifocal melanoma of multiple organ systems.
Core Tip: Malignant melanoma is becoming more common among middle-aged individuals all over the world. Melanoma metastasis can be found in various organs, although multiple metastases to the spleen and stomach are rare. Herein we present a rare metastatic multifocal melanoma, clinically and histologically mimicking lymphoma, with metastases of multiple organs including spleen, stomach, bones, lungs, liver, lymph nodes. This case report highlights the clinical relevance of metastatic multifocal melanoma.
