Xiang XL, Cao YH, Jiang TW, Huang ZR. Intravitreous injection of conbercept for bullous retinal detachment: A case report. World J Clin Cases 2022; 10(26): 9510-9517 [PMID: 36159403 DOI: 10.12998/wjcc.v10.i26.9510]
Corresponding Author of This Article
Zheng-Ru Huang, MD, PhD, Chief Doctor, Professor, Department of Ophthalmology, The Affiliated Changshu Hospital of Xuzhou Medical University, No. 68 Haiyu South Road, Changshu 215500, Jiangsu Province, China. hzhengru@163.com
Research Domain of This Article
Ophthalmology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Xiao-Li Xiang, Yi-Hong Cao, Zheng-Ru Huang, Department of Ophthalmology, The Affiliated Changshu Hospital of Xuzhou Medical University, Changshu 215500, Jiangsu Province, China
Ting-Wang Jiang, Department of Key Laboratory, The Affiliated Changshu Hospital of Xuzhou Medical University, Changshu 215500, Jiangsu Province, China
Author contributions: Xiang XL, Cao YH, and Huang ZR contributed to conception and design; Xiang XL, and Jiang TW contributed to data collection and collation; Xiang XL contributed to manuscript writing; Huang ZR contributed to definition of intellectual content, data interpretation and final review of the manuscript; all authors have read and approved the final manuscript.
Supported byGuiding Project of Changshu Health Committee, No. CSWZD202021; Project of the Affiliated Changshu Hospital of Xuzhou Medical University, No. CSEY202125.
Informed consent statement: The authors are accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee(s) and with the Helsinki Declaration (as revised in 2013). Written informed consent was obtained from the patient for publication of this case report and accompanying images. A copy of the written consent is available for review by the editorial office of this journal.
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Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zheng-Ru Huang, MD, PhD, Chief Doctor, Professor, Department of Ophthalmology, The Affiliated Changshu Hospital of Xuzhou Medical University, No. 68 Haiyu South Road, Changshu 215500, Jiangsu Province, China. hzhengru@163.com
Received: May 9, 2022 Peer-review started: May 9, 2022 First decision: June 16, 2022 Revised: June 25, 2022 Accepted: August 16, 2022 Article in press: August 16, 2022 Published online: September 16, 2022 Processing time: 116 Days and 0 Hours
Abstract
BACKGROUND
Diffuse retinal pigment epitheliopathy (DRPE) associated with bullous retinal detachment is a severe variant of DRPE that is frequently misdiagnosed and often improperly treated.
CASE SUMMARY
A 36-year-old female patient complained of "painless vision decline in the left eye with obscuration for 10 d". Slit-lamp microscopic fundus examination revealed white-yellow subretinal exudates in the posterior pole in both eyes, retinal detachment with shifting subretinal fluid in the left eye, and no retinal hiatus. Fundus fluorescein angiography revealed multiple subretinal leakage foci and localized hypofluorescent lesions with patched hyperfluorescence. There was fluorescence leakage in the retinal vessels in the retinal detachment area and occluded blood vessels in the lower and peripheral areas. Indocyanine green angiography revealed multifocal lamellar hyperfluorescence in the middle stage and low fluorescence in the retinal detachment area in the late stage. Retinal anatomical reduction significantly improved with intravitreal conbercept injections.
CONCLUSION
Intravitreal injection of conbercept can anatomically reattach the retina in patients with bullous retinal detachment.
Core Tip: The study patient exhibited a considerable improvement in retinal anatomical reduction after intravitreal injections of conbercept. Nevertheless, due to the the macular area destruction, we observed unsatisfactory improvement in best-corrected visual acuity. Based on the study findings, intravitreal injection of a vascular endothelial growth factor inhibitor may be a considered potent therapeutic option for cases of bullous retinal detachment of diffuse retinal pigment epitheliopathy. This treatment is uncomplicated and harmless and precludes adopting complex surgical techniques associated with high risk of complications.
