Mu Y, Li JJ, Wu X, Zhou XF, Tang L, Zhou Q. Cefoperazone-sulbactam and ornidazole for Gardnerella vaginalis bloodstream infection after cesarean section: A case report. World J Clin Cases 2022; 10(26): 9323-9331 [PMID: 36159406 DOI: 10.12998/wjcc.v10.i26.9323]
Corresponding Author of This Article
Jing-Jing Li, PharmD, Pharmacist, Department of Pharmacy, The Affiliated Suzhou Hospital, Nanjing Medical University/Suzhou Municipal Hospital, No. 26 Daoqian Street, Gusu District, Suzhou 215002, Jiangsu Province, China. lijingno.2@163.com
Research Domain of This Article
Pharmacology & Pharmacy
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Yu Mu, National Clinical Pharmacist Training Base, The Affiliated Suzhou Hospital, Nanjing Medical University/Suzhou Municipal Hospital, Suzhou 215002, Jiangsu Province, China
Yu Mu, Department of Pharmacy, Xuzhou Maternity and Child Health Hospital/Affiliated Xuzhou Maternity and Child Health Hospital, Xuzhou Medical University, Xuzhou 221000, Jiangsu Province, China
Jing-Jing Li, Lian Tang, Qin Zhou, Department of Pharmacy, The Affiliated Suzhou Hospital, Nanjing Medical University/Suzhou Municipal Hospital, Suzhou 215002, Jiangsu Province, China
Xiao Wu, Xin-Fang Zhou, Department of Obstetrics, The Affiliated Suzhou Hospital, Nanjing Medical University/Suzhou Municipal Hospital, Suzhou 215002, Jiangsu Province, China
Author contributions: Mu Y and Li JJ contributed equally to this work; Mu Y and Li JJ designed the research study; Mu Y, Li JJ, Wu X and Zhou XF collected the data; Mu Y, Li JJ, Lang L and Zhou Q analyzed the data and wrote the manuscript; all authors have read and approved the final manuscript.
Informed consent statement: Written informed consent was obtained from the patient for the publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jing-Jing Li, PharmD, Pharmacist, Department of Pharmacy, The Affiliated Suzhou Hospital, Nanjing Medical University/Suzhou Municipal Hospital, No. 26 Daoqian Street, Gusu District, Suzhou 215002, Jiangsu Province, China. lijingno.2@163.com
Received: March 20, 2022 Peer-review started: March 20, 2022 First decision: May 12, 2022 Revised: May 23, 2022 Accepted: August 6, 2022 Article in press: August 6, 2022 Published online: September 16, 2022
Abstract
BACKGROUND
Gardnerella vaginalis (G. vaginalis) is a facultative anaerobic bacteria known to cause bloodstream infections. However, cases are very rare in clinics. There is very limited clinical experience in the treatment of bloodstream infections caused by G. vaginalis. Therefore, there is an urgent need for effective antibacterial drugs to treat patients with bloodstream infections caused by G. vaginalis.
CASE SUMMARY
A woman who underwent a cesarean section presented with a sudden onset of high fever 1-d post-surgery. The blood cultures suggested an infection due to G. vaginalis, and treatment with cefoperazone-sulbactam was started. After 5 d of treatment, there was a decrease in the hemogram; however, the temperature and C-reactive protein levels remained high. Based on clinical experience and a review of literature, the treatment was modified to include ornidazole in combination with cefoperazone-sulbactam. Following a week of treatment, the temperature, hemogram and C-reactive protein levels returned to normal, and blood cultures turned negative, suggesting a therapeutic effect of the combination treatment.
CONCLUSION
This case highlighted the effective use of cefoperazone-sulbactam combined with ornidazole for bloodstream infection caused by G. vaginalis following a cesarean section.
Core Tip: We analyzed a case of bloodstream infection caused by Gardnerella vaginalis after cesarean section. We believe that our study makes a significant contribution to the literature because it indicates that cefoperazone-sulbactam combined with ornidazole is an effective therapy for bloodstream infection caused by Gardnerella vaginalis after cesarean section.
