Gonçalves Júnior J, Sampaio-Barros PD, Shinjo SK. Reflections on the prevalence of human leukocyte antigen-B27 and human leukocyte antigen-B51 co-occurrence in patients with spondylarthritis. World J Clin Cases 2022; 10(23): 8422-8424 [PMID: 36159538 DOI: 10.12998/wjcc.v10.i23.8422]
Corresponding Author of This Article
Jucier Gonçalves Júnior, MD, Academic Research, Division of Rheumatology, São Paulo University, Avenida Doutor Arnaldo, 715-São Paulo-SP-Brasil-CEP 01246904, São Paulo 01246-903, São Paulo, Brazil. juciergjunior@hotmail.com
Research Domain of This Article
Rheumatology
Article-Type of This Article
Letter to the Editor
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Aug 16, 2022; 10(23): 8422-8424 Published online Aug 16, 2022. doi: 10.12998/wjcc.v10.i23.8422
Reflections on the prevalence of human leukocyte antigen-B27 and human leukocyte antigen-B51 co-occurrence in patients with spondylarthritis
Jucier Gonçalves Júnior, Percival Degrava Sampaio-Barros, Samuel Katsuyuki Shinjo
Jucier Gonçalves Júnior, Percival Degrava Sampaio-Barros, Samuel Katsuyuki Shinjo, Division of Rheumatology, São Paulo University, São Paulo 01246-903, São Paulo, Brazil
Author contributions: All authors contributed equally to all aspects of this manuscript preparation and have read and approved the final manuscript.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jucier Gonçalves Júnior, MD, Academic Research, Division of Rheumatology, São Paulo University, Avenida Doutor Arnaldo, 715-São Paulo-SP-Brasil-CEP 01246904, São Paulo 01246-903, São Paulo, Brazil. juciergjunior@hotmail.com
Received: March 14, 2022 Peer-review started: March 14, 2022 First decision: May 11, 2022 Revised: May 14, 2022 Accepted: July 18, 2022 Article in press: July 18, 2022 Published online: August 16, 2022
Abstract
We performed a literature mini-review of the clinical profile of patients with spondylarthritis who are also human leukocyte antigen (HLA)-B51-positive. It seems to us that patients with HLA-B27 and HLA-B51 are more common in men, Asians and between the third and ninth decades of life. They are more likely to develop peripheral joint conditions, with cutaneous manifestations (e.g., oral ulcers) and uveitis. Therefore, more robust epidemiological studies with more accurate methodology and multicenter locations are needed to better map the role of the interaction between HLA-B51 in patients with spondylarthritis.
Core Tip: Patients with human leukocyte antigen-B51 and human leukocyte antigen-B17 tend to be male, Asians and between the third and ninth decades of life with more peripheral arthritis, uveitis and oral ulcers.
