Tao Y, Nan Q, Lei Z, Miao YL, Niu JK. Rare primary rectal mucosa-associated lymphoid tissue lymphoma with curative resection by endoscopic submucosal dissection: A case report and review of literature. World J Clin Cases 2022; 10(21): 7599-7608 [PMID: 36158004 DOI: 10.12998/wjcc.v10.i21.7599]
Corresponding Author of This Article
Jun-Kun Niu, MD, PhD, Doctor, Department of Gastroenterology, The First Affiliated Hospital of Kunming Medical University; Yunnan Province Clinical Research Center for Digestive Diseases, No. 295 Xichang Road, Kunming 650032, Yunnan Province, China. drnjk@qq.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Jul 26, 2022; 10(21): 7599-7608 Published online Jul 26, 2022. doi: 10.12998/wjcc.v10.i21.7599
Rare primary rectal mucosa-associated lymphoid tissue lymphoma with curative resection by endoscopic submucosal dissection: A case report and review of literature
Yan Tao, Qiong Nan, Zi Lei, Ying-Lei Miao, Jun-Kun Niu
Yan Tao, Qiong Nan, Ying-Lei Miao, Jun-Kun Niu, Department of Gastroenterology, The First Affiliated Hospital of Kunming Medical University; Yunnan Province Clinical Research Center for Digestive Diseases, Kunming 650032, Yunnan Province, China
Zi Lei, Department of Pathology, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan Province, China
Author contributions: Tao Y wrote the manuscript; Nan Q and Niu JK performed endoscopic submucosal dissection for the patient; Niu JK and Miao YL revised the manuscript; Lei Z contributed to the histopathology and immunohistochemistry staining; and All authors approved the final manuscript to be published.
Supported byNational Natural Science Foundation of China, No. U1802282, No. 81960108, No. 82170550, and No. 82160107; Applied Basic Research Projects of Yunnan Province, No. 2019FE001(036); Yunnan Health Training Project of High Level Talents, No. H-2019050 and Yunnan Ten Thousand Talents Plan Young and Elite Talents Project.
Informed consent statement: Written informed consent from the patient was obtained.
Conflict-of-interest statement: All authors declare that they have no conflict of interest to report.
CARE Checklist (2016) statement: We have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jun-Kun Niu, MD, PhD, Doctor, Department of Gastroenterology, The First Affiliated Hospital of Kunming Medical University; Yunnan Province Clinical Research Center for Digestive Diseases, No. 295 Xichang Road, Kunming 650032, Yunnan Province, China. drnjk@qq.com
Received: March 12, 2022 Peer-review started: March 12, 2022 First decision: May 11, 2022 Revised: May 19, 2022 Accepted: June 15, 2022 Article in press: June 15, 2022 Published online: July 26, 2022 Processing time: 120 Days and 17.4 Hours
Abstract
BACKGROUND
Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) occurs in approximately 9% of non-Hodgkin B-cell lymphomas. The gastrointestinal tract is the most commonly affected site of the extranodal forms of primary non-Hodgkin’s lymphomas. However, it rarely occurs within the rectum, and at present, there is no consensus on its diagnosis and treatment at this site.
CASE SUMMARY
We report a rare laterally spreading tumour-like rectal MALT lymphoma case in which the diagnosis and the depth of infiltration were determined by magnifying endoscopy and ultrasonic endoscopy. Then, the lesion was en bloc resected by endoscopic submucosal dissection (ESD) alone. The lesion was confirmed as MALT lymphoma by haematoxylin and eosin staining, immunohistochemical staining and gene arrangement analysis. Surveillance exams have indicated a 2-year disease-free survival for this patient.
CONCLUSION
We report a rare primary rectal MALT lymphoma that was curable with resection by ESD. ESD is a safe and effective therapeutic option for rectal MALT lymphoma.
Core Tip: Primary rectal extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) is a rare clinical entity. The clinical symptoms and endoscopic findings are nonspecific. The patient in this case was diagnosed with low-grade rectal MALT lymphoma, which was limited to the mucosa based on magnifying endoscopy, histopathological features, immunohistochemical tests, and gene rearrangement analyses. The lesion was en bloc resected by endoscopic submucosal dissection alone.
