Yan YY, Lai C, Wu L, Fu Y. Extranasopharyngeal angiofibroma in children: A case report. World J Clin Cases 2022; 10(21): 7429-7437 [PMID: 36158007 DOI: 10.12998/wjcc.v10.i21.7429]
Corresponding Author of This Article
Yong Fu, Doctor, PhD, Chief Doctor, Professor, Surgeon, Department of Otorhinolaryngology, Head and Neck Surgery, the Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, No. Binsheng Road 3333, Hangzhou 310052, Zhejiang Province, China. 1307022@zju.edu.cn
Research Domain of This Article
Surgery
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Jul 26, 2022; 10(21): 7429-7437 Published online Jul 26, 2022. doi: 10.12998/wjcc.v10.i21.7429
Extranasopharyngeal angiofibroma in children: A case report
Yang-Yan Yan, Can Lai, Lei Wu, Yong Fu
Yang-Yan Yan, Yong Fu, Department of Otorhinolaryngology, Head and Neck Surgery, the Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou 310052, Zhejiang Province, China
Can Lai, Department of Radiology, the Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou 310052, Zhejiang Province, China
Lei Wu, Department of Endoscopy Center, the Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou 310052, Zhejiang Province, China
Author contributions: Yan YY and Fu Y contributed equally to this work; Yan YY, Lai C, Wu L and Fu Y participated the treatment of disease. Yan YY and Fu Y analyzed the case and wrote the manuscript; all authors have read and approve the final manuscript.
Informed consent statement: Written informed consent was obtained from individual participants.
Conflict-of-interest statement: This paper has not been published elsewhere in whole or in part. All authors have read and approved the content, and agree to submit it for consideration for publication in your journal. There are no conflict of interest related to the manuscript.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yong Fu, Doctor, PhD, Chief Doctor, Professor, Surgeon, Department of Otorhinolaryngology, Head and Neck Surgery, the Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, No. Binsheng Road 3333, Hangzhou 310052, Zhejiang Province, China. 1307022@zju.edu.cn
Received: September 24, 2021 Peer-review started: September 24, 2021 First decision: December 2, 2021 Revised: December 11, 2021 Accepted: June 3, 2022 Article in press: June 3, 2022 Published online: July 26, 2022 Processing time: 289 Days and 18.4 Hours
Abstract
BACKGROUND
Sporadic cases of extranasopharyngeal angiofibroma in children, especially preschool children, have been reported in the literature.
CASE SUMMARY
We present a case of extranasopharyngeal angiofibroma in a 4-year-old boy. The presenting symptoms, imaging findings, treatment, histological appearance, and follow-up data are described in detail. For this patient, we performed embolization on two occasions, and then, resected the tumor completely. During the treatment, the patient developed a soft-palate perforation due to aseptic necrosis. However, the healing ability was good, and the perforation healed spontaneously. We additionally reviewed all pediatric cases of extranasopharyngeal angiofibroma published up to 30 June 2020 in the PubMed, Baidu Scholar, Scopus, and Web of Science databases. We identified 45 pediatric patients [average (10.98 ± 4.86), boys 39 (86.7%)]. The highest proportion of cases occurred in adolescence [22 (48.9%)]. The top three sites of occurrence of extranasopharyngeal angiofibroma in children were the maxillary sinus, nasal septum, and inferior turbinate.
CONCLUSION
Extranasopharyngeal angiofibromas can occur throughout childhood, and predominantly present with nasal obstruction and spontaneous rhinorrhagia.
Core Tip: Extranasopharyngeal angiofibromas can occur throughout childhood, but predominantly occur during adolescence. They present with similar symptoms. In our case, the clinical presentation was unusual due to the patient’s young age, the large tumor size, and the requirement of two embolization treatments. Soft palate perforation developed as a complication, but healed spontaneously during follow-up. Additionally, we performed a literature review to summarize the clinical characteristics of this rare tumor.
