Dharan M, Wozny D. Helicobacter pylori infection and small intestinal bacterial overgrowth–more than what meets the eye. World J Clin Cases 2022; 10(21): 7209-7214 [PMID: 36158005 DOI: 10.12998/wjcc.v10.i21.7209]
Corresponding Author of This Article
Murali Dharan, FASGE, MRCP, Assistant Professor, Department of Gastroenterology and Hepatology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, United States. dharan@uchc.edu
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Jul 26, 2022; 10(21): 7209-7214 Published online Jul 26, 2022. doi: 10.12998/wjcc.v10.i21.7209
Helicobacter pylori infection and small intestinal bacterial overgrowth–more than what meets the eye
Murali Dharan, David Wozny
Murali Dharan, Department of Gastroenterology and Hepatology, University of Connecticut Health Center, Farmington, CT 06030, United States
David Wozny, Department of Primary Care and Internal Medicine, University of Connecticut, Farmington, CT 06030, United States
Author contributions: Dharan M contributed to the conceptualization, literature search, drafting of article and major revisions; Wozny D contributed to the literature search, drafting of article and revision.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Murali Dharan, FASGE, MRCP, Assistant Professor, Department of Gastroenterology and Hepatology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, United States. dharan@uchc.edu
Received: January 14, 2022 Peer-review started: January 14, 2022 First decision: March 8, 2022 Revised: April 18, 2022 Accepted: June 14, 2022 Article in press: June 14, 2022 Published online: July 26, 2022 Processing time: 177 Days and 9.6 Hours
Abstract
Helicobacter pylori (H. pylori) infection is very common and affects a significant proportion of the world population. In contrast, the prevalence of small intestinal bacterial overgrowth (SIBO) in the general population is not well understood. There can be coexistence of both disease states in a given patient and their clinical symptoms may also overlap with one and another. There is no clear clinical guidelines for testing for and treating SIBO in patients with H. pylori infection. This review article explores the available evidence on the relationship between H. pylori infection and SIBO, diagnosis and treatment of these entities and also comments on associated non-gastrointestinal conditions.
Core Tip: This article explores the coexistence of small intestinal bacterial overgrowth (SIBO) in patients with Helicobacter pylori (H. pylori) infection including epidemiology and pathophysiologic mechanisms. It also reviews diagnosis and treatment of these entities and highlights current knowledge gaps and areas of future research. Currently, there are no guidelines for evaluation and management of co-existent SIBO in H. pylori infection.
