Case Report
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jul 16, 2022; 10(20): 6960-6965
Published online Jul 16, 2022. doi: 10.12998/wjcc.v10.i20.6960
Lower lip recurrent keratoacanthoma: A case report
Xian-Guang Liu, Xing-Guang Liu, Cai-Jiao Wang, Han-Xi Wang, Xu-Xia Wang
Xian-Guang Liu, Xing-Guang Liu, Han-Xi Wang, Xu-Xia Wang, Department of Oral and Maxillofacial Surgery, Shandong University, Jinan 250100, Shandong Province, China
Cai-Jiao Wang, Department of Oral Pathology, Shandong University, Jinan 250100, Shandong Province, China
Author contributions: Liu XianG, Liu XingG, Wang CJ, Wang HX designed the research study; Liu XianG, Wang CJ, Wang HX performed the research; Liu XingG, Wang XX contributed analytic tools; Liu XianG, Liu XingG, Wang CJ, Wang XX analyzed the data and wrote the manuscript; All authors have read and approve the final manuscript.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xu-Xia Wang, Doctor, Department of Oral and Maxillofacial Surgery, Shandong University, No. 44-1 Wenhua West Road, Jinan 250012, Shandong Province, China. wangxuxia2021@163.com
Received: September 26, 2021
Peer-review started: September 26, 2021
First decision: March 14, 2022
Revised: March 16, 2022
Accepted: May 26, 2022
Article in press: May 26, 2022
Published online: July 16, 2022
Processing time: 281 Days and 2.5 Hours
Abstract
BACKGROUND

This paper introduces a case of recurrent keratoacanthoma (KA). KA is a self-healing disease. Recurrence after surgical resection is rare. In this case, the local application of retinoic acid ointment after the second operation achieved a good prognosis after 2 years of follow-up.

CASE SUMMARY

A 76-year-old male patient was admitted to the hospital for "lower lip rupture and scab for 3 mo". Treatment: A rectangular incision was made in the healthy tissue about 3 mm outside the periphery of the lower lip mass, and a modified Bernard sliding flap was designed to completely remove the mass. Pathology showed (lower lip) KA. When the patient returned 6 mo after surgery, the middle mucosa of the lower lip had a bulge with a diameter of about 0.5 cm. The boundary was still clear, the surface was ulcerated. A recurrence of lower lip KA was suspected and a fan-shaped incision was performed in the healthy tissue about 5 mm outside the lesion to completely resect. Pathological showed lower lip KA had recurred. Topical application of tretinoin cream was applied once a day for 3 mo. The lower lip wounds were clean at the 2-year postoperative follow-up and the mucosa was normal.

CONCLUSION

Adjuvant retinoic acid treatment after KA surgical resection can achieve good results.

Keywords: Keratoacanthoma; Lower lip; Squamous cell carcinoma; Clinical features; Recurrence; Case report

Core Tip: Keratoacanthoma of the lower lip is a rare benign tumour with unique clinical and pathological characteristics which are very similar to those of well-differentiated squamous cell carcinoma of the lower lip. This article reports on an elderly male patient with recurrent lower lip keratoacanthoma, describing its clinical and pathological characteristics and treatment measures. Through reviewing the relevant literature and analysing the causes of the disease, clinical manifestations, pathological characteristics, treatment options, and causes of recurrence, it is possible to further deepen the understanding of the disease and help determine the diagnosis and treatment.