Fan ZN, Shi HJ, Xiong BB, Zhang JS, Wang HF, Wang JS. Primary adrenal diffuse large B-cell lymphoma with normal adrenal cortex function: A case report. World J Clin Cases 2022; 10(2): 709-716 [PMID: 35097098 DOI: 10.12998/wjcc.v10.i2.709]
Corresponding Author of This Article
Jin-Song Zhang, Doctor, Department of Urology, The Second Affiliated Hospital, Kunming Medical University, No. 374 Dianmian Avenue, Wuhua District, Kunming 650000, Yunnan Province, China. 945933392zjs@sina.com
Research Domain of This Article
Urology & Nephrology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Zhi-Nan Fan, Hong-Jin Shi, Bo-Bo Xiong, Jin-Song Zhang, Hai-Feng Wang, Jian-Song Wang, Department of Urology, The Second Affiliated Hospital, Kunming Medical University, Kunming 650000, Yunnan Province, China
Author contributions: Fan ZN, Shi HJ, and Xiong BB reviewed the literature and contributed to manuscript drafting; Zhang JS was responsible for the revision of the manuscript for important intellectual content; Wang HF and Wang JS provided technical guidance; all authors issued final approval for the version to be submitted.
Supported byNational Natural Science Foundation of China, No. 82060464 and No. 81972395.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jin-Song Zhang, Doctor, Department of Urology, The Second Affiliated Hospital, Kunming Medical University, No. 374 Dianmian Avenue, Wuhua District, Kunming 650000, Yunnan Province, China. 945933392zjs@sina.com
Received: July 31, 2021 Peer-review started: July 31, 2021 First decision: October 22, 2021 Revised: November 2, 2021 Accepted: December 10, 2021 Article in press: December 10, 2021 Published online: January 14, 2022
Abstract
BACKGROUND
Diffuse large B-cell lymphoma, which accounts for about approximately 30% to 40% of non-Hodgkin's lymphomas, is the most common type and is a class of aggressive B-cell lymphomas. However, diffuse large B-cell lymphomas primary to the adrenal gland are rare.
CASE SUMMARY
A 73-year-old man was admitted with abdominal pain and fatigue. After admission, enhanced adrenal computed tomography indicated irregular masses on both adrenal glands, with the larger one on the left side, approximately 8.0 cm × 4.3 cm in size. The boundary was irregular, and surrounding tissues were compressed. No obvious enhancement was observed in the arterial phase. Resection of the left adrenal gland was performed. Pathological diagnosis revealed diffuse large B-cell lymphoma. After surgery, the patient received R-CHOP immunochemotherapy. During the fourth immunochemotherapy, patient condition deteriorated, and he eventually died of respiratory failure.
CONCLUSION
R-CHOP is the conventional immunochemotherapy for primary adrenal diffuse large B-cell lymphoma. Surgery is mainly used to diagnose the disease. Hence, the ideal treatment plan remains to be confirmed.
Core Tip: Primary adrenal diffuse large B-cell lymphoma is a rare disease with no consistent treatment standards. The R-CHOP regimen is the conventional immunochemotherapy regimen for this disease. We report a case of surgery combined with immunochemotherapy; however, immunochemotherapy was ineffective and the patient eventually died of respiratory failure. Therefore, the optimal treatment of primary adrenal diffuse large B-cell lymphoma remains to be further explored.
