Wang JY, Wang ZQ, Liang SC, Li GX, Shi JL, Wang JL. Plastic surgery for giant metastatic endometrioid adenocarcinoma in the abdominal wall: A case report and review of literature. World J Clin Cases 2022; 10(19): 6702-6709 [PMID: 35979309 DOI: 10.12998/wjcc.v10.i19.6702]
Corresponding Author of This Article
Jian-Liu Wang, MD, PhD, Doctor, Professor, Surgeon, Surgical Oncologist, Department of Obstetrics and Gynecology, Peking University People's Hospital, No. 11 Xizhimen South Street, Xicheng District, Beijing 100044, China. wangjianliu1203@163.com
Research Domain of This Article
Obstetrics & Gynecology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Jing-Yuan Wang, Zhi-Qi Wang, Si-Chen Liang, Jian-Liu Wang, Department of Obstetrics and Gynecology, Peking University People's Hospital, Beijing 100044, China
Guang-Xue Li, Department of Plastic Surgery, Peking University People’s Hospital, Beijing 100044, China
Jing-Li Shi, Department of Pathology, Peking University People’s Hospital, Beijing 100044, China
Author contributions: Wang JY participated in the management of the patient and wrote the manuscript; Wang ZQ participated in the medical management of the patient; Liang SC and Wang JL were involved in the surgical management of the patient; Li GX carried out plastic surgery; Shi JL performed immunohistochemistry and contributed to pathological characterization.
Supported byThis work was supported by the National Key Technology R&D Program of China, No. 2019YFC1005200, and No. 2019YFC1005201; the Natural Science Foundation of Beijing, No. 7202213; and the National Natural Science Foundation of China; No. 82072861, 81672571, and 81874108.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jian-Liu Wang, MD, PhD, Doctor, Professor, Surgeon, Surgical Oncologist, Department of Obstetrics and Gynecology, Peking University People's Hospital, No. 11 Xizhimen South Street, Xicheng District, Beijing 100044, China. wangjianliu1203@163.com
Received: January 23, 2022 Peer-review started: January 23, 2022 First decision: March 23, 2022 Revised: April 1, 2022 Accepted: May 8, 2022 Article in press: May 8, 2022 Published online: July 6, 2022 Processing time: 151 Days and 19.4 Hours
Abstract
BACKGROUND
Endometrial cancer (EC) is a common gynecological malignancy, but metastasis to the abdominal wall is extremely rare. Therefore, an appropriate treatment approach for large metastatic lesions with infection remains a great challenge.
CASE SUMMARY
We report the case of a 65-year-old woman who developed abdominal metastasis of endometrioid adenocarcinoma, as defined by International Obstetrics and Gynecology stage II, in which the lesion was complicated by infection. A right hemicolectomy was performed for colon metastasis in relation to her initial gynecological cancer 3 years ago. When admitted to our department, a complete resection of the giant abdominal wall lesion was performed, and a Bard composite mesh was used to reconstruct the abdominal wall. A local flap was used to close the resultant large defect in the external covering of the abdomen. The patient underwent chemotherapy following cytoreductive surgery. Pathology revealed metastasis of EC, and molecular subtyping showed copy number high of TP53 mutation, implying a poor prognosis.
CONCLUSION
When EC patients develop giant abdominal wall metastasis, a plastic surgeon should be included before contemplating resection of tumors.
Core Tip: This report presents a rare case of endometrioid adenocarcinoma with extensive abdominal wall metastasis complicated by infection, and highlights the design of the reconstruction of the abdominal wall after resection. A plastic surgeon should be included in the planning before contemplating resection of large tumors.
