Peng HY, Xiu YJ, Chen WH, Gu QL, Du X. Follicular lymphoma presenting like marginal zone lymphoma: A case report. World J Clin Cases 2022; 10(17): 5877-5883 [PMID: 35979114 DOI: 10.12998/wjcc.v10.i17.5877]
Corresponding Author of This Article
Xin Du, PhD, Chief Doctor, Department of Hematology, Shenzhen Second People’s Hospital, The First Affiliated Hospital of Shenzhen University, No. 3002 Sungang West Road, Futian District, Shenzhen 518035, Guangdong Province, China. duxingz@medmail.com.cn
Research Domain of This Article
Pathology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Jun 16, 2022; 10(17): 5877-5883 Published online Jun 16, 2022. doi: 10.12998/wjcc.v10.i17.5877
Follicular lymphoma presenting like marginal zone lymphoma: A case report
Hao-Yu Peng, Ying-Jie Xiu, Wei-Hong Chen, Qing-Li Gu, Xin Du
Hao-Yu Peng, Wei-Hong Chen, Qing-Li Gu, Xin Du, Department of Hematology, Shenzhen Second People’s Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen 518035, Guangdong Province, China
Ying-Jie Xiu, Department of Pathology, Shenzhen Second People’s Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen 518035, Guangdong Province, China
Author contributions: Peng HY wrote the manuscript; Xiu YJ provided the pathological pictures and contributed to the diagnosis; Chen WH reviewed the cases and edited the manuscript; Gu QL was in charge of the follow-up; Du X designed the study; all authors issued final approval for the version to be submitted; All authors approved the manuscript for publication.
Informed consent statement: Written informed consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xin Du, PhD, Chief Doctor, Department of Hematology, Shenzhen Second People’s Hospital, The First Affiliated Hospital of Shenzhen University, No. 3002 Sungang West Road, Futian District, Shenzhen 518035, Guangdong Province, China. duxingz@medmail.com.cn
Received: December 29, 2021 Peer-review started: December 29, 2021 First decision: March 7, 2022 Revised: March 20, 2022 Accepted: April 4, 2022 Article in press: April 4, 2022 Published online: June 16, 2022 Processing time: 161 Days and 15.7 Hours
Abstract
BACKGROUND
Follicular lymphoma (FL), a common type of indolent lymphoma, carries markers of the germinal center, and the rearrangement of the BCL-2 gene is regarded as an initiating event and a hallmark of the neoplasm. When FL has marginal zone differentiation, some marginal zone features are carried by the neoplasm.
CASE SUMMARY
A 54-year-old male with lymphadenopathy, splenomegaly and hyperlymphocytosis was diagnosed with FL with marginal zone differentiation. The tumor demonstrated different features in the bone marrow (BM) compared with the follicle of the lymph node (LN). Some component of the neoplasm mimicked marginal zone lymphoma, such as infiltrating the marginal zone of the LN, displaying a monocytoid shape and lacking the expression of CD10 in the BM. The diagnosis of FL was made due to the concurrent detection of BCL-2 rearrangement in the LN and BM.
CONCLUSION
Discordant pathological features in LN and BM could mislead diagnosis. When clinical and pathological manifestations are confusing in diagnosis, typical genetic abnormalities are decisive.
Core Tip: We reported a case of follicular lymphoma presenting like marginal zone lymphoma due to its marginal zone differentiation and made the diagnosis according to the detection of the rearrangement of BCL-2.
