Published online May 6, 2022. doi: 10.12998/wjcc.v10.i13.4153
Peer-review started: August 6, 2021
First decision: January 10, 2022
Revised: January 21, 2022
Accepted: March 17, 2022
Article in press: March 17, 2022
Published online: May 6, 2022
Processing time: 266 Days and 19.8 Hours
Primary hyperparathyroidism (PHPT) is the most common cause of pregnancy-related hypercalcemia. PHPT can cause maternal and fetal complications in pregnant women. General anesthesia for non-obstetric surgery in pregnant women is associated with maternal hazards and concerns regarding long-term neonatal neurocognitive effects. Surgical removal of the lesion in mid-pregnancy is currently the primary treatment option for pregnant patients with PHPT. However, the blood calcium concentration at which surgery should be considered remains under discussion due to the risk of miscarriage.
A 31-year-old nulliparous woman at 11 wk of gestation was admitted to our hospital for parathyroidectomy. The patient had a history of intrauterine fetal death with unknown etiology at 16 wk of gestation 1 year prior. Her blood test results showed that the serum calcium level was elevated to 12.9 mg/dL, and the parathyroid hormone level was elevated to 157 pg/mL. In a neck ultrasound, it revealed a 0.8 cm × 1.5 cm sized oval, hypoechoic mass in the upper posterior of the left thyroid gland, which was compatible with parathyroid adenoma. Superficial cervical plexus block (SCPB) for parathyroidectomy was performed. After surgery, the obstetrician checked the status of the fetus, and there were no abnormal signs. Since then her calcium level returned to normal values after one week of surgery and a healthy male neonate of 2910 g was delivered vaginally at 38 wk of gestation.
Our case suggests that SCPB can be an anesthetic option for parathyroidectomy during the first trimester of pregnancy.
Core Tip: Pregnant women undergoing general anesthesia for non-obstetric surgery have risks of maternal hazards. In addition, the surgery might affect the long-term development of the fetus in early pregnancy and cause premature birth in late pregnancy. Pregnant patient with severe primary hyperparathyroidism (PHPT), such as our case, should have their calcium concentration lowered before surgery. Surgical removal of the lesion in mid-pregnancy is the treatment-of-choice in PHPT. However, in case of persisting hypercalcemia despite of conservative treatment, superficial cervical plexus block can be an anesthetic option for parathyroidectomy during the first trimester of pregnancy.