Wang CH, Jin HF, Liu WG, Guo Y, Liu Z. Acute pancreatitis-induced thrombotic thrombocytopenic purpura: A case report. World J Clin Cases 2022; 10(12): 3808-3813 [PMID: 35647154 DOI: 10.12998/wjcc.v10.i12.3808]
Corresponding Author of This Article
Chun-Hua Wang, MD, Chief Doctor, Department of Gastroenterology, The 980th Hospital of the People's Liberation Army Joint Service (Bethune International Peace Hospital), No. 398 Zhongshanxi Road, Shijiazhuang 050082, Hebei Province, China. crown99@126.com
Research Domain of This Article
Medicine, General & Internal
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Apr 26, 2022; 10(12): 3808-3813 Published online Apr 26, 2022. doi: 10.12998/wjcc.v10.i12.3808
Acute pancreatitis-induced thrombotic thrombocytopenic purpura: A case report
Chun-Hua Wang, Hai-Feng Jin, Wen-Ge Liu, Ying Guo, Zhen Liu
Chun-Hua Wang, Hai-Feng Jin, Wen-Ge Liu, Ying Guo, Zhen Liu, Department of Gastroenterology, The 980th Hospital of the People's Liberation Army Joint Service (Bethune International Peace Hospital), Shijiazhuang 050082, Hebei Province, China
Author contributions: Wang CH, Jin HF and Liu WG contributed to the planning, conduction and report of the work; Wang CH and Guo Y contributed to the conception and design of the work; Wang CH and Liu Z contributed to the acquisition of analysis and interpretation of the results; All authors have read and approved the manuscript.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: No potential conflicts of interest relevant to this article were reported.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016) and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Chun-Hua Wang, MD, Chief Doctor, Department of Gastroenterology, The 980th Hospital of the People's Liberation Army Joint Service (Bethune International Peace Hospital), No. 398 Zhongshanxi Road, Shijiazhuang 050082, Hebei Province, China. crown99@126.com
Received: December 7, 2021 Peer-review started: December 7, 2021 First decision: January 25, 2022 Revised: February 15, 2022 Accepted: March 7, 2022 Article in press: March 7, 2022 Published online: April 26, 2022 Processing time: 135 Days and 3.5 Hours
Abstract
BACKGROUND
Thrombotic thrombocytopenic purpura (TTP) is a life-threatening but treatable disorder. Acute pancreatitis is a well-described consequence of TTP, but TTP as a consequence of acute pancreatitis is rare.
CASE SUMMARY
A 32-year-old male developed acute pancreatitis due to a fatty diet and suffered splenectomy 3 years ago due to trauma. From day 4 of his onset of pain the blood examination showed the platelet extremely reduced, bilirubin elevated and creatinine increased. High clinical suspicion of TTP was made and prompt initiation of plasma exchange was given followed intravenous drip methylprednisolone. After 7 sessions of plasm exchange and the laboratory parameters were back to normal and the patient was discharged from the hospital on the 13th day of admission.
CONCLUSION
Patients develop acute pancreatitis with no apparent causes for hemolytic anemia and thrombocytopenia, the possibility of TTP should be considered. Treatments for TTP including plasm exchange should be evaluated as soon as a diagnosis is made.
Core Tip: This subject is a rare case report encountered in clinical work. Acute pancreatitis accompanied thrombotic thrombocytopenic purpura is fatal but treatable. Highly recognized this disease could save lives. When acute pancreatitis accompanied hemolytic anemia, thrombocytopenia, renal impairment, fever, and neurological disorders, a high index of clinical suspicion of thrombotic thrombocytopenic purpura is required for prompt diagnosis and early treatment, which is associated with good outcome.
