Current understanding of adult nephrotic syndrome: Minimal change disease

doi:10.5527/wjn.v14.i1.101930

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Mar 25, 2025 (publication date) through Jan 21, 2025

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World Journal of Nephrology

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2220-6124

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Nephrol. Mar 25, 2025; 14(1): 101930
Published online Mar 25, 2025. doi: 10.5527/wjn.v14.i1.101930

Current understanding of adult nephrotic syndrome: Minimal change disease

Krishna Kumar Govindarajan

Krishna Kumar Govindarajan, Department of Pediatric Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry 605006, India

Author contributions: Govindarajan KK conceptualized and reviewed the manuscript; the author read and approved the final version of the manuscript to be published.

Conflict-of-interest statement: The author declares no conflict of interest in publishing the manuscript.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Krishna Kumar Govindarajan, FACS, MBBS, MCh, MD, MNAMS, Professor, Department of Pediatric Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research, JIPMER Campus Road, Gorimedu, Dhanvantari Nagar, Puducherry 605006, India. kkpeds@gmail.com

Received: October 8, 2024
Revised: December 24, 2024
Accepted: January 7, 2025
Published online: March 25, 2025
Processing time: 111 Days and 2.1 Hours

Core Tip

Core Tip: Minimal change disease (MCD) represents a unique type of nephrotic syndrome in adults. MCD pathogenesis has been previously attributed to several mechanisms, though they did not explain all of the features and therapeutic implications of MCD. The recent identification of zinc fingers and homeobox transcriptional factors has provided a new dimension to understand and provide better management in MCD.