Govindarajan KK. Current understanding of adult nephrotic syndrome: Minimal change disease. World J Nephrol 2025; 14(1): 101930 [DOI: 10.5527/wjn.v14.i1.101930]
Corresponding Author of This Article
Krishna Kumar Govindarajan, FACS, MBBS, MCh, MD, MNAMS, Professor, Department of Pediatric Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research, JIPMER Campus Road, Gorimedu, Dhanvantari Nagar, Puducherry 605006, India. kkpeds@gmail.com
Research Domain of This Article
Medicine, Research & Experimental
Article-Type of This Article
Letter to the Editor
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Nephrol. Mar 25, 2025; 14(1): 101930 Published online Mar 25, 2025. doi: 10.5527/wjn.v14.i1.101930
Current understanding of adult nephrotic syndrome: Minimal change disease
Krishna Kumar Govindarajan
Krishna Kumar Govindarajan, Department of Pediatric Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry 605006, India
Author contributions: Govindarajan KK conceptualized and reviewed the manuscript; the author read and approved the final version of the manuscript to be published.
Conflict-of-interest statement: The author declares no conflict of interest in publishing the manuscript.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Krishna Kumar Govindarajan, FACS, MBBS, MCh, MD, MNAMS, Professor, Department of Pediatric Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research, JIPMER Campus Road, Gorimedu, Dhanvantari Nagar, Puducherry 605006, India. kkpeds@gmail.com
Received: October 8, 2024 Revised: December 24, 2024 Accepted: January 7, 2025 Published online: March 25, 2025 Processing time: 111 Days and 2.1 Hours
Abstract
The underlying molecular changes that result in minimal change disease (nephrotic syndrome) require an in-depth analysis. Current molecular studies have shown the involvement of zinc fingers and homeobox transcriptional factors in its pathogenesis. The application of therapeutic drugs relies on understanding the cascade of molecular events to determine their efficacy in managing the clinical condition.
Core Tip: Minimal change disease (MCD) represents a unique type of nephrotic syndrome in adults. MCD pathogenesis has been previously attributed to several mechanisms, though they did not explain all of the features and therapeutic implications of MCD. The recent identification of zinc fingers and homeobox transcriptional factors has provided a new dimension to understand and provide better management in MCD.
