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World J Nephrol. Jun 25, 2024; 13(2): 93322
Published online Jun 25, 2024. doi: 10.5527/wjn.v13.i2.93322
Obstructive uropathy: Overview of the pathogenesis, etiology and management of a prevalent cause of acute kidney injury
Xabier Pérez-Aizpurua, Ramiro Cabello Benavente, Gonzalo Bueno Serrano, José María Alcázar Peral, Blanca Gómez-Jordana Mañas, Jaime Tufet i Jaumot, Joaquín Ruiz de Castroviejo Blanco, Felipe Osorio Ospina, Carmen Gonzalez-Enguita
Xabier Pérez-Aizpurua, Ramiro Cabello Benavente, Gonzalo Bueno Serrano, José María Alcázar Peral, Blanca Gómez-Jordana Mañas, Jaime Tufet i Jaumot, Joaquín Ruiz de Castroviejo Blanco, Felipe Osorio Ospina, Carmen Gonzalez-Enguita, Department of Urology, Hospital Universitario Fundación Jiménez Díaz, Madrid 28015, Madrid, Spain
Author contributions: Pérez-Aizpurua X revised the literature and wrote the manuscript; Gómez-Jordana B, Tufet i Jaumot J, Ruiz de Castroviejo J and Osorio F revised the literature and provided selected articles for inclusion; Cabello R, Bueno G, Alcázar JM and González-Enguita revised the manuscript; All authors have read and approved the final manuscript.
Conflict-of-interest statement: All the authors declare that they have no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xabier Pérez-Aizpurua, MD, Doctor, Department of Urology, Hospital Universitario Fundación Jiménez Díaz, Avda. Reyes Católicos 2, Madrid 28015, Madrid, Spain.xabier.perez@quironsalud.es
Received: February 26, 2024
Revised: May 24, 2024
Accepted: June 18, 2024
Published online: June 25, 2024
Processing time: 119 Days and 11.2 Hours
Core Tip

Core Tip: Obstructive uropathy is a prevalent cause of acute kidney injury that can potentially lead to death or irreversible and permanent tissue damage leading to chronic kidney disease. It is of vital importance to perform a correct initial assessment in order to identify patients that may benefit from early urinary diversion. Acute obstruction of the urinary tract leads to volume overload, electrolyte imbalances and infectious complications that need to be correctly addressed, therefore, a multidisciplinary team is key. Management of urinary tract obstruction does not end after urinary diversion. Timing and adequate management of such condition will determine renal recovery following obstruction.