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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Virol. Mar 25, 2025; 14(1): 100489
Published online Mar 25, 2025. doi: 10.5501/wjv.v14.i1.100489
Published online Mar 25, 2025. doi: 10.5501/wjv.v14.i1.100489
Pathogenesis and clinical management of arboviral diseases
Victoria Cenci Dietrich, Juan Marcos Caram Costa, Marina Maria Gomes Leite Oliveira, Carlos Eduardo Oliveira Aguiar, Luis Guilherme de Oliveira Silva, Marcel Silva Luz, Fabian Fellipe Bueno Lemos, Fabrício Freire de Melo, Instituto Multidisciplinar em Saúde, Universidade Federal da Bahia, Vitória da Conquista 45029-094, Bahia, Brazil
Co-corresponding authors: Fabian Fellipe Bueno Lemos and Fabrício Freire de Melo.
Author contributions: Dietrich VC, Costa JMC, Oliveira MMGL, and Aguiar CEO researched the content, developed the article, and created the tables and illustrations; In addition, Dietrich VC, as the first author, also systematized the text, developed the abstract, introduction, conclusion, and handled the guidelines for the preparation and submission of the review; Lemos FFB, Silva LGO, Luz LMS, and de Melo FF reviewed the articles during the writing process, providing suggestions, and directing the research; Lemos FFB and de Melo FF contributed equally to this work as co-corresponding authors; de Melo FF, as the corresponding author, thoroughly reviewed the entire article; and all the cited authors contributed significantly to the production of the article.
Supported by the Permanecer Program (part of the actions of the Office of Affirmative Actions); Education and Diversity of the Dean of Student Assistance at the Federal University of Bahia (UFBA); and CNPq Research Productivity Fellow.
Conflict-of-interest statement: All authors declare no potential conflicts of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Fabrício Freire de Melo, PhD, Assistant Professor, Instituto Mul
Received: August 18, 2024
Revised: October 1, 2024
Accepted: October 28, 2024
Published online: March 25, 2025
Processing time: 102 Days and 1.1 Hours
Revised: October 1, 2024
Accepted: October 28, 2024
Published online: March 25, 2025
Processing time: 102 Days and 1.1 Hours
Core Tip
Core Tip: This review delves into the historical characteristics, pathogenesis, and clinical management of the four major arboviruses that have triggered outbreaks worldwide: Dengue, Zika, yellow fever, and chikungunya fever. It aims to elucidate the viral characteristics, cellular tropism, and immune evasion mechanisms, as well as the primary clinical manifestations and their complications, laboratory diagnosis, treatment, prevention, and vaccines either currently available or under development. Thus, with a focus on the medical and scientific fields, this review enables the reader to acquire comprehensive and generalized knowledge about each of these arboviruses.