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World J Transplant. Mar 18, 2024; 14(1): 89025
Published online Mar 18, 2024. doi: 10.5500/wjt.v14.i1.89025
Artificial kidney: Challenges and opportunities
Filippos F Karageorgos, Stavros Neiros, Konstantina-Eleni Karakasi, Stella Vasileiadou, Georgios Katsanos, Nikolaos Antoniadis, Georgios Tsoulfas
Filippos F Karageorgos, Stavros Neiros, Konstantina-Eleni Karakasi, Stella Vasileiadou, Georgios Katsanos, Nikolaos Antoniadis, Georgios Tsoulfas, Department of Transplantation Surgery, Center for Research and Innovation in Solid Organ Transplantation, Aristotle University School of Medicine, Thessaloniki 54642, Greece
Author contributions: Karageorgos FF performed the conceptualization; Karageorgos FF, Neiros S, Karakasi KE, Vasileiadou S, Katsanos G, Antoniadis N and Tsoulfas G contributed to the resources; Karageorgos FF contributed to the data curation; Karageorgos FF wrote the original draft; Karageorgos FF, Neiros S, Karakasi KE, Vasileiadou S, Katsanos G, Antoniadis N and Tsoulfas G wrote the review and edited; Tsoulfas G performed the supervision.
Conflict-of-interest statement: All authors have no conflict of interest to disclose.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Georgios Tsoulfas, FACS, FICS, MD, PhD, Chief, Department of Transplantation Surgery, Center for Research and Innovation in Solid Organ Transplantation, Aristotle University School of Medicine, 49 Konstantinoupoleos Street, Thessaloniki 54622, Greece. tsoulfasg@gmail.com
Received: October 18, 2023
Peer-review started: October 18, 2023
First decision: December 29, 2023
Revised: January 17, 2024
Accepted: February 4, 2024
Article in press: February 4, 2024
Published online: March 18, 2024
Processing time: 149 Days and 1.1 Hours
Core Tip

Core Tip: Different technologies of artificial kidneys have been proposed and still there is no one capable of fully replacing the renal function properly. Many problems such as bioavailability, potential contamination and other variables must be controlled to make such a device successful. Herein, the most important efforts for the creation of wearable and implantable kidneys are mentioned and in addition, the principles that these devices should be governed are discussed as well.