Karageorgos FF, Neiros S, Karakasi KE, Vasileiadou S, Katsanos G, Antoniadis N, Tsoulfas G. Artificial kidney: Challenges and opportunities. World J Transplant 2024; 14(1): 89025 [PMID: 38576754 DOI: 10.5500/wjt.v14.i1.89025]
Corresponding Author of This Article
Georgios Tsoulfas, FACS, FICS, MD, PhD, Chief, Department of Transplantation Surgery, Center for Research and Innovation in Solid Organ Transplantation, Aristotle University School of Medicine, 49 Konstantinoupoleos Street, Thessaloniki 54622, Greece. tsoulfasg@gmail.com
Research Domain of This Article
Transplantation
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Filippos F Karageorgos, Stavros Neiros, Konstantina-Eleni Karakasi, Stella Vasileiadou, Georgios Katsanos, Nikolaos Antoniadis, Georgios Tsoulfas, Department of Transplantation Surgery, Center for Research and Innovation in Solid Organ Transplantation, Aristotle University School of Medicine, Thessaloniki 54642, Greece
Author contributions: Karageorgos FF performed the conceptualization; Karageorgos FF, Neiros S, Karakasi KE, Vasileiadou S, Katsanos G, Antoniadis N and Tsoulfas G contributed to the resources; Karageorgos FF contributed to the data curation; Karageorgos FF wrote the original draft; Karageorgos FF, Neiros S, Karakasi KE, Vasileiadou S, Katsanos G, Antoniadis N and Tsoulfas G wrote the review and edited; Tsoulfas G performed the supervision.
Conflict-of-interest statement: All authors have no conflict of interest to disclose.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Georgios Tsoulfas, FACS, FICS, MD, PhD, Chief, Department of Transplantation Surgery, Center for Research and Innovation in Solid Organ Transplantation, Aristotle University School of Medicine, 49 Konstantinoupoleos Street, Thessaloniki 54622, Greece. tsoulfasg@gmail.com
Received: October 18, 2023 Peer-review started: October 18, 2023 First decision: December 29, 2023 Revised: January 17, 2024 Accepted: February 4, 2024 Article in press: February 4, 2024 Published online: March 18, 2024
Abstract
This review aims to present the developments occurring in the field of artificial organs and particularly focuses on the presentation of developments in artificial kidneys. The challenges for biomedical engineering involved in overcoming the potential difficulties are showcased, as well as the importance of interdisciplinary collaboration in this marriage of medicine and technology. In this review, modern artificial kidneys and the research efforts trying to provide and promise artificial kidneys are presented. But what are the problems faced by each technology and to what extent is the effort enough to date?
Core Tip: Different technologies of artificial kidneys have been proposed and still there is no one capable of fully replacing the renal function properly. Many problems such as bioavailability, potential contamination and other variables must be controlled to make such a device successful. Herein, the most important efforts for the creation of wearable and implantable kidneys are mentioned and in addition, the principles that these devices should be governed are discussed as well.
