Simforoosh N, Shemshaki H, Nadjafi-Semnani M, Sotoudeh M. Living related and living unrelated kidney transplantations: A systematic review and meta-analysis. World J Transplant 2017; 7(2): 152-160 [PMID: 28507918 DOI: 10.5500/wjt.v7.i2.152]
Corresponding Author of This Article
Nasser Simforoosh, Professor, Department of Urology, Shahid Labbafi Nejad Hospital, Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, 9th Boostan Avenue, Pasdaran Avenue, Tehran 198396-3113, Iran. simforoosh@iurtc.org.ir
Research Domain of This Article
Transplantation
Article-Type of This Article
Meta-Analysis
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Transplant. Apr 24, 2017; 7(2): 152-160 Published online Apr 24, 2017. doi: 10.5500/wjt.v7.i2.152
Living related and living unrelated kidney transplantations: A systematic review and meta-analysis
Nasser Simforoosh, Hamidreza Shemshaki, Mohammad Nadjafi-Semnani, Mehdi Sotoudeh
Nasser Simforoosh, Hamidreza Shemshaki, Mohammad Nadjafi-Semnani, Mehdi Sotoudeh, Department of Urology, Shahid Labbafi Nejad Hospital, Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran 198396-3113, Iran
Author contributions: Simforoosh N, Shemshaki H, Nadjafi-Semnani M and Sotoudeh M acquisition of data, analysis and interpretation of data, drafting the article and final approval; Sotoudeh M interpretation of data, revising the article and final approval.
Conflict-of-interest statement: The authors deny any conflict of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Nasser Simforoosh, Professor, Department of Urology, Shahid Labbafi Nejad Hospital, Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, 9th Boostan Avenue, Pasdaran Avenue, Tehran 198396-3113, Iran. simforoosh@iurtc.org.ir
Telephone: +98-21-22588018 Fax: +98-21-22588016
Received: November 21, 2016 Peer-review started: November 23, 2016 First decision: January 16, 2017 Revised: February 20, 2017 Accepted: April 6, 2017 Article in press: April 10, 2017 Published online: April 24, 2017 Processing time: 150 Days and 18.1 Hours
Abstract
AIM
To compare the outcomes between related and unrelated kidney transplantations.
METHODS
Literature searches were performed following the Cochrane guidelines. We conducted a systematic review and a meta-analysis, which included 12 trials that investigated outcomes including the long-term (ten years), mid-term (one to five years), and short-term (one year) graft survival rate as well as the acute rejection rate. Meta-analyses were performed using fixed and random-effects models, which included tests for publication bias and heterogeneity.
RESULTS
No difference in graft survival rate was detected in patients who underwent living related kidney transplantations compared to unrelated (P = 0.44) transplantations after ten years. There were no significant differences between the graft survival rate in living related and unrelated kidney transplantations after a short- and mid-term follow-up (P = 0.35, P = 0.46). There were no significant differences between the acute rejection rate in living related and unrelated kidney transplantations (P = 0.06).
CONCLUSION
The long, mid and short term follow-up of living related and unrelated kidney transplantation showed no significant difference in graft survival rate. Also, acute rejection rate was not significantly different between groups.
Core tip: The long, mid and short term follow-up of living related and unrelated kidney transplantation showed no significant difference in graft survival rate. Also, acute rejection rate was not significantly different between groups.
